Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-09-04 | Florida A&M (146) | 3 | Jackson State (126) | 59 | Final | W | 56 |
| 2 | 2022-09-10 | Jackson State (126) | 16 | Tennessee State (202) | 3 | Final | W | 13 |
| 3 | 2022-09-17 | Grambling (207) | 24 | Jackson State (135) | 66 | Final | W | 42 |
| 4 | 2022-09-24 | Mississippi Valley State (260) | 7 | Jackson State (136) | 49 | Final | W | 42 |
| 5 | 2022-10-08 | Jackson State (135) | 26 | Alabama State (211) | 12 | Final | W | 14 |
| 6 | 2022-10-15 | Jackson State (130) | 48 | Bethune-Cookman (252) | 8 | Final | W | 40 |
| 7 | 2022-10-22 | Campbell (164) | 14 | Jackson State (120) | 22 | Final | W | 8 |
| 8 | 2022-10-29 | Southern (174) | 0 | Jackson State (112) | 35 | Final | W | 35 |
| 9 | 2022-11-05 | Jackson State (105) | 41 | Texas Southern (193) | 14 | Final | W | 27 |
| 10 | 2022-11-12 | Jackson State (109) | 27 | Alabama A&M (230) | 13 | Final | W | 14 |
| 11 | 2022-11-19 | Jackson State (105) | 24 | Alcorn State (211) | 13 | Final | W | 11 |
| 12 | 2022-12-03 | Southern (181) | 24 | Jackson State (106) | 43 | Final | W | 19 |
| 13 | 2022-12-17 | Jackson State (106) | 34 | North Carolina Central (164) | 41 | Final(OT) | L | -7 |