Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-09-03 | Grambling (187) | 3 | Arkansas State (151) | 58 | Final | W | 55 |
| 2 | 2022-09-10 | Arkansas State (151) | 12 | Ohio State (4) | 45 | Final | L | -33 |
| 3 | 2022-09-17 | Arkansas State (93) | 32 | Memphis (62) | 44 | Final | L | -12 |
| 4 | 2022-09-24 | Arkansas State (107) | 26 | Old Dominion (82) | 29 | Final | L | -3 |
| 5 | 2022-10-01 | Louisiana-Monroe (102) | 28 | Arkansas State (85) | 45 | Final | W | 17 |
| 6 | 2022-10-08 | James Madison (14) | 42 | Arkansas State (89) | 20 | Final | L | -22 |
| 7 | 2022-10-15 | Arkansas State (103) | 19 | Southern Miss (73) | 20 | Final | L | -1 |
| 8 | 2022-10-22 | Arkansas State (114) | 18 | Louisiana (86) | 38 | Final | L | -20 |
| 9 | 2022-10-29 | South Alabama (45) | 31 | Arkansas State (121) | 3 | Final | L | -28 |
| 10 | 2022-11-12 | Massachusetts (172) | 33 | Arkansas State (118) | 35 | Final | W | 2 |
| 11 | 2022-11-19 | Arkansas State (126) | 13 | Texas State (117) | 16 | Final | L | -3 |
| 12 | 2022-11-26 | Troy (25) | 48 | Arkansas State (129) | 19 | Final | L | -29 |