Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-09-03 | Stephen F. Austin (148) | 31 | Alcorn State (197) | 27 | Final | L | -4 |
| 2 | 2022-09-10 | Alcorn State (197) | 0 | Tulane (114) | 52 | Final | L | -52 |
| 3 | 2022-09-17 | Alcorn State (212) | 30 | McNeese State (256) | 19 | Final | W | 11 |
| 4 | 2022-09-24 | Arkansas-Pine Bluff (229) | 21 | Alcorn State (187) | 38 | Final | W | 17 |
| 5 | 2022-10-08 | Alcorn State (194) | 30 | Mississippi Valley State (260) | 7 | Final | W | 23 |
| 6 | 2022-10-15 | Alcorn State (201) | 17 | Southern (170) | 21 | Final | L | -4 |
| 7 | 2022-10-22 | Texas Southern (184) | 34 | Alcorn State (215) | 27 | Final | L | -7 |
| 8 | 2022-10-29 | Alcorn State (226) | 6 | Grambling (229) | 35 | Final | L | -29 |
| 9 | 2022-11-04 | Alcorn State (216) | 23 | Prairie View A&M (178) | 16 | Final(OT) | W | 7 |
| 10 | 2022-11-12 | Bethune-Cookman (247) | 14 | Alcorn State (211) | 17 | Final | W | 3 |
| 11 | 2022-11-19 | Jackson State (105) | 24 | Alcorn State (211) | 13 | Final | L | -11 |