NCAA Women's Basketball Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | South Carolina State (340) | 52 | 80 | Old Dominion (130) | Final | L | -28 |
| 2 | 2021-11-13 | Coastal Carolina (322) | 81 | 57 | South Carolina State (340) | Final | L | -24 |
| 3 | 2021-11-16 | South Carolina Upstate (274) | 70 | 51 | South Carolina State (294) | Final | L | -19 |
| 4 | 2021-11-18 | St. Thomas (218) | 65 | 50 | South Carolina State (355) | Final | L | -15 |
| 5 | 2021-11-26 | South Carolina State (355) | 57 | 72 | Georgia Southern (78) | Final | L | -15 |
| 6 | 2021-11-27 | South Carolina State (355) | 43 | 75 | Jacksonville State (223) | Final | L | -32 |
| 7 | 2021-12-01 | Campbell (239) | 67 | 46 | South Carolina State (353) | Final | L | -21 |
| 8 | 2021-12-04 | South Carolina State (355) | 46 | 86 | North Carolina A&T (264) | Final | L | -40 |
| 9 | 2021-12-12 | Western Carolina (316) | 61 | 52 | South Carolina State (354) | Final | L | -9 |
| 10 | 2021-12-15 | South Carolina State (353) | 40 | 94 | Wake Forest (33) | Final | L | -54 |
| 11 | 2021-12-18 | South Carolina State (355) | 37 | 97 | Jackson State (314) | Final | L | -60 |
| 12 | 2021-12-19 | Troy (67) | 94 | 51 | South Carolina State (355) | Final | L | -43 |
| 13 | 2021-12-20 | South Carolina State (353) | 47 | 85 | Mississippi State (73) | Final | L | -38 |
| 14 | 2021-12-29 | Furman (250) | 47 | 32 | South Carolina State (353) | Final | L | -15 |
| 15 | 2022-01-08 | Coppin State (311) | 0 | 0 | South Carolina State (355) | Postponed | - | - |
| 16 | 2022-01-10 | Morgan State (351) | 0 | 0 | South Carolina State (355) | Postponed | - | - |
| 17 | 2022-01-15 | North Carolina Central (335) | 51 | 63 | South Carolina State (353) | Final | W | 12 |
| 18 | 2022-01-22 | South Carolina State (352) | 54 | 50 | Maryland-Eastern Shore (318) | Final | W | 4 |
| 19 | 2022-01-24 | South Carolina State (352) | 53 | 48 | Delaware State (351) | Final | W | 5 |
| 20 | 2022-01-29 | Norfolk State (213) | 60 | 40 | South Carolina State (340) | Final | L | -20 |
| 21 | 2022-01-31 | Howard (116) | 67 | 59 | South Carolina State (355) | Final | L | -8 |
| 22 | 2022-02-05 | Coppin State (311) | 84 | 55 | South Carolina State (355) | Final | L | -29 |
| 23 | 2022-02-07 | Morgan State (351) | 73 | 49 | South Carolina State (355) | Final | L | -24 |
| 24 | 2022-02-12 | South Carolina State (343) | 55 | 80 | Coppin State (226) | Final | L | -25 |
| 25 | 2022-02-14 | South Carolina State (343) | 48 | 76 | Morgan State (207) | Final | L | -28 |
| 26 | 2022-02-19 | Maryland-Eastern Shore (318) | 65 | 57 | South Carolina State (344) | Final | L | -8 |
| 27 | 2022-02-21 | Delaware State (356) | 52 | 64 | South Carolina State (344) | Final | W | 12 |
| 28 | 2022-02-26 | South Carolina State (344) | 29 | 68 | Norfolk State (226) | Final | L | -39 |
| 29 | 2022-02-28 | South Carolina State (344) | 48 | 64 | Howard (216) | Final | L | -16 |
| 30 | 2022-03-03 | South Carolina State (347) | 74 | 84 | North Carolina Central (341) | Final | L | -10 |
| 31 | 2022-03-10 | South Carolina State (349) | 53 | 66 | Morgan State (201) | Final | L | -13 |