NCAA Women's Basketball Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | East Tennessee State (311) | 54 | 81 | Cleveland State (173) | Final | L | -27 |
| 2 | 2021-11-11 | East Tennessee State (212) | 58 | 90 | Bowling Green (188) | Final | L | -32 |
| 3 | 2021-11-14 | Cornell | 54 | 66 | East Tennessee State (311) | Final | W | 12 |
| 4 | 2021-11-17 | Georgia Tech (7) | 65 | 42 | East Tennessee State (238) | Final | L | -23 |
| 5 | 2021-11-23 | East Tennessee State (212) | 55 | 63 | Presbyterian (357) | Final | L | -8 |
| 6 | 2021-11-26 | Gardner-Webb (303) | 78 | 72 | East Tennessee State (212) | Final | L | -6 |
| 7 | 2021-11-28 | East Tennessee State (278) | 41 | 55 | Coastal Carolina (86) | Final | L | -14 |
| 8 | 2021-12-01 | East Tennessee State (315) | 53 | 81 | Appalachian State (180) | Final | L | -28 |
| 9 | 2021-12-10 | UNC-Asheville (251) | 66 | 56 | East Tennessee State (322) | Final | L | -10 |
| 10 | 2021-12-13 | East Tennessee State (322) | 58 | 90 | Wake Forest (34) | Final | L | -32 |
| 11 | 2021-12-16 | East Tennessee State (326) | 48 | 61 | Jacksonville State (165) | Final | L | -13 |
| 12 | 2021-12-20 | East Tennessee State (326) | 58 | 112 | Tennessee (3) | Final | L | -54 |
| 13 | 2021-12-23 | St. Bonaventure (176) | 56 | 49 | East Tennessee State (335) | Final | L | -7 |
| 14 | 2022-01-02 | Lynchburg | 0 | 0 | East Tennessee State (212) | Canceled | - | - |
| 15 | 2022-01-06 | East Tennessee State (335) | 0 | 0 | Mercer (121) | Postponed | - | - |
| 16 | 2022-01-08 | East Tennessee State (212) | 0 | 0 | Samford (256) | Postponed | - | - |
| 17 | 2022-01-15 | Chattanooga (313) | 66 | 46 | East Tennessee State (334) | Final | L | -20 |
| 18 | 2022-01-17 | East Tennessee State (334) | 54 | 66 | Mercer (115) | Final | L | -12 |
| 19 | 2022-01-20 | UNC-Greensboro (312) | 56 | 38 | East Tennessee State (338) | Final | L | -18 |
| 20 | 2022-01-22 | Western Carolina (331) | 45 | 68 | East Tennessee State (338) | Final | W | 23 |
| 21 | 2022-01-27 | East Tennessee State (212) | 54 | 68 | Furman (198) | Final | L | -14 |
| 22 | 2022-01-29 | East Tennessee State (336) | 51 | 73 | Wofford (229) | Final | L | -22 |
| 23 | 2022-02-03 | Samford (263) | 69 | 76 | East Tennessee State (338) | Final | W | 7 |
| 24 | 2022-02-05 | Mercer (245) | 82 | 48 | East Tennessee State (212) | Final | L | -34 |
| 25 | 2022-02-07 | East Tennessee State (212) | 61 | 73 | Samford (256) | Final | L | -12 |
| 26 | 2022-02-12 | East Tennessee State (333) | 65 | 62 | Chattanooga (306) | Final | W | 3 |
| 27 | 2022-02-17 | East Tennessee State (333) | 58 | 51 | Western Carolina (339) | Final | W | 7 |
| 28 | 2022-02-19 | East Tennessee State (333) | 46 | 50 | UNC-Greensboro (319) | Final | L | -4 |
| 29 | 2022-02-24 | Wofford (202) | 64 | 70 | East Tennessee State (331) | Final | W | 6 |
| 30 | 2022-02-26 | Furman (253) | 62 | 51 | East Tennessee State (331) | Final | L | -11 |
| 31 | 2022-03-03 | East Tennessee State (327) | 54 | 66 | Wofford (209) | Final | L | -12 |