NCAA Women's Basketball Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | East Carolina (170) | 49 | 70 | Middle Tennessee (81) | Final | L | -21 |
| 2 | 2021-11-12 | East Carolina (106) | 50 | 60 | High Point (103) | Final | L | -10 |
| 3 | 2021-11-15 | Gardner-Webb (268) | 52 | 81 | East Carolina (170) | Final | W | 29 |
| 4 | 2021-11-18 | Hampton (305) | 58 | 75 | East Carolina (106) | Final | W | 17 |
| 5 | 2021-11-21 | East Carolina (239) | 52 | 73 | Wake Forest (8) | Final | L | -21 |
| 6 | 2021-11-23 | Coppin State (311) | 44 | 75 | East Carolina (106) | Final | W | 31 |
| 7 | 2021-11-28 | Campbell (224) | 66 | 76 | East Carolina (211) | Final | W | 10 |
| 8 | 2021-12-01 | East Carolina (124) | 48 | 65 | Virginia Commonwealth (65) | Final | L | -17 |
| 9 | 2021-12-04 | Towson (199) | 66 | 51 | East Carolina (106) | Final | L | -15 |
| 10 | 2021-12-06 | North Carolina Central (334) | 34 | 75 | East Carolina (124) | Final | W | 41 |
| 11 | 2021-12-16 | East Carolina (151) | 59 | 75 | North Carolina A&T (266) | Final | L | -16 |
| 12 | 2021-12-19 | East Carolina (106) | 79 | 50 | UNC-Wilmington (324) | Final | W | 29 |
| 13 | 2021-12-21 | Maryland-Eastern Shore (313) | 57 | 85 | East Carolina (175) | Final | W | 28 |
| 14 | 2022-01-01 | East Carolina (164) | 0 | 0 | SMU (134) | Postponed | - | - |
| 15 | 2022-01-08 | Central Florida (150) | 52 | 43 | East Carolina (106) | Final | L | -9 |
| 16 | 2022-01-11 | East Carolina (171) | 59 | 71 | Tulsa (97) | Final | L | -12 |
| 17 | 2022-01-13 | East Carolina (106) | 49 | 60 | SMU (209) | Final | L | -11 |
| 18 | 2022-01-16 | Cincinnati (122) | 48 | 71 | East Carolina (106) | Final | W | 23 |
| 19 | 2022-01-19 | Temple (151) | 56 | 41 | East Carolina (106) | Final | L | -15 |
| 20 | 2022-01-25 | East Carolina (174) | 55 | 70 | Wichita State (126) | Final | L | -15 |
| 21 | 2022-01-29 | East Carolina (174) | 55 | 75 | Tulane (82) | Final | L | -20 |
| 22 | 2022-02-03 | SMU (87) | 58 | 46 | East Carolina (193) | Final | L | -12 |
| 23 | 2022-02-06 | East Carolina (193) | 59 | 60 | Temple (111) | Final | L | -1 |
| 24 | 2022-02-09 | Wichita State (266) | 59 | 61 | East Carolina (106) | Final/OT | W | 2 |
| 25 | 2022-02-13 | Memphis (106) | 38 | 68 | East Carolina (200) | Final | W | 30 |
| 26 | 2022-02-16 | East Carolina (106) | 55 | 67 | Houston (180) | Final | L | -12 |
| 27 | 2022-02-19 | East Carolina (171) | 68 | 57 | Cincinnati (175) | Final | W | 11 |
| 28 | 2022-02-24 | Tulsa (115) | 0 | 0 | East Carolina (166) | Canceled | - | - |
| 29 | 2022-02-27 | South Florida (34) | 68 | 60 | East Carolina (166) | Final | L | -8 |
| 30 | 2022-03-02 | East Carolina (170) | 53 | 56 | Memphis (124) | Final | L | -3 |
| 31 | 2022-03-07 | East Carolina (170) | 48 | 59 | Memphis (124) | Final | L | -11 |