NCAA Women's Basketball Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Wake Forest (48) | 68 | 55 | Mercer (118) | Final | L | -13 |
| 2 | 2021-11-11 | Appalachian State (226) | 57 | 61 | Mercer (245) | Final | W | 4 |
| 3 | 2021-11-15 | Troy (80) | 66 | 75 | Mercer (118) | Final | W | 9 |
| 4 | 2021-11-18 | Mercer (245) | 52 | 67 | Georgia (30) | Final | L | -15 |
| 5 | 2021-11-21 | Mercer (80) | 63 | 50 | Gardner-Webb (355) | Final | W | 13 |
| 6 | 2021-11-24 | Mercer (119) | 48 | 55 | Alabama (84) | Final | L | -7 |
| 7 | 2021-11-26 | Mercer (245) | 67 | 53 | South Alabama (194) | Final | W | 14 |
| 8 | 2021-11-29 | Kennesaw State (295) | 49 | 66 | Mercer (119) | Final | W | 17 |
| 9 | 2021-12-03 | Mercer (99) | 49 | 59 | Middle Tennessee (44) | Final | L | -10 |
| 10 | 2021-12-05 | Mercer (99) | 71 | 70 | Tennessee State (265) | Final/OT | W | 1 |
| 11 | 2021-12-12 | Central Florida (21) | 61 | 47 | Mercer (119) | Final | L | -14 |
| 12 | 2021-12-19 | UAB (217) | 62 | 71 | Mercer (245) | Final | W | 9 |
| 13 | 2021-12-21 | Bethune-Cookman (336) | 0 | 0 | Mercer (120) | Cancelled | - | - |
| 14 | 2021-12-28 | UNC-Wilmington (324) | 0 | 0 | Mercer (245) | Cancelled | - | - |
| 15 | 2021-12-31 | LaGrange | 0 | 0 | Mercer (245) | Cancelled | - | - |
| 16 | 2022-01-06 | East Tennessee State (335) | 0 | 0 | Mercer (121) | Postponed | - | - |
| 17 | 2022-01-08 | Chattanooga (187) | 52 | 69 | Mercer (245) | Final | W | 17 |
| 18 | 2022-01-13 | Mercer (245) | 66 | 60 | UNC-Greensboro (254) | Final | W | 6 |
| 19 | 2022-01-15 | Mercer (115) | 69 | 58 | Western Carolina (330) | Final | W | 11 |
| 20 | 2022-01-17 | East Tennessee State (334) | 54 | 66 | Mercer (115) | Final | W | 12 |
| 21 | 2022-01-20 | Furman (260) | 69 | 66 | Mercer (117) | Final | L | -3 |
| 22 | 2022-01-22 | Wofford (236) | 53 | 67 | Mercer (117) | Final | W | 14 |
| 23 | 2022-01-29 | Samford (261) | 66 | 73 | Mercer (132) | Final | W | 7 |
| 24 | 2022-02-03 | Mercer (121) | 59 | 53 | Chattanooga (301) | Final | W | 6 |
| 25 | 2022-02-05 | Mercer (245) | 82 | 48 | East Tennessee State (212) | Final | W | 34 |
| 26 | 2022-02-10 | Western Carolina (353) | 40 | 46 | Mercer (245) | Final | W | 6 |
| 27 | 2022-02-12 | UNC-Greensboro (314) | 43 | 75 | Mercer (119) | Final | W | 32 |
| 28 | 2022-02-17 | Mercer (116) | 74 | 57 | Wofford (199) | Final | W | 17 |
| 29 | 2022-02-19 | Mercer (116) | 71 | 64 | Furman (253) | Final | W | 7 |
| 30 | 2022-02-26 | Mercer (107) | 64 | 55 | Samford (266) | Final | W | 9 |
| 31 | 2022-03-03 | Western Carolina (342) | 46 | 85 | Mercer (106) | Final | W | 39 |
| 32 | 2022-03-04 | Samford (270) | 35 | 65 | Mercer (106) | Final | W | 30 |
| 33 | 2022-03-06 | Furman (238) | 54 | 73 | Mercer (106) | Final | W | 19 |
| 34 | 2022-03-19 | Mercer (97) | 38 | 83 | Connecticut (7) | Final | L | -45 |