NCAA Women's Basketball Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Elon (149) | 68 | 66 | High Point (150) | Final | L | -2 |
| 2 | 2021-11-12 | East Carolina (106) | 50 | 60 | High Point (103) | Final | W | 10 |
| 3 | 2021-11-14 | Mid-Atlantic | 38 | 109 | High Point (150) | Final | W | 71 |
| 4 | 2021-11-20 | High Point (133) | 54 | 76 | Davidson (182) | Final | L | -22 |
| 5 | 2021-11-24 | Wake Forest (24) | 79 | 50 | High Point (155) | Final | L | -29 |
| 6 | 2021-11-30 | High Point (163) | 52 | 74 | Wofford (311) | Final | L | -22 |
| 7 | 2021-12-04 | High Point (103) | 47 | 70 | Liberty (144) | Final | L | -23 |
| 8 | 2021-12-09 | King | 56 | 76 | High Point (249) | Final | W | 20 |
| 9 | 2021-12-17 | High Point (237) | 46 | 62 | South Florida (29) | Final | L | -16 |
| 10 | 2021-12-20 | High Point (237) | 64 | 71 | Dayton (97) | Final | L | -7 |
| 11 | 2021-12-21 | Florida Gulf Coast (35) | 86 | 50 | High Point (251) | Final | L | -36 |
| 12 | 2021-12-29 | Gardner-Webb (309) | 64 | 50 | High Point (254) | Final | L | -14 |
| 13 | 2022-01-01 | High Point (254) | 0 | 0 | Charleston Southern (356) | Postponed | - | - |
| 14 | 2022-01-04 | Radford (296) | 0 | 0 | High Point (288) | Postponed | - | - |
| 15 | 2022-01-08 | High Point (103) | 0 | 0 | South Carolina Upstate (315) | Postponed | - | - |
| 16 | 2022-01-11 | High Point (283) | 0 | 0 | Winthrop (356) | Postponed | - | - |
| 17 | 2022-01-12 | High Point (103) | 83 | 73 | South Carolina Upstate (315) | Final | W | 10 |
| 18 | 2022-01-15 | Campbell (198) | 58 | 50 | High Point (283) | Final | L | -8 |
| 19 | 2022-01-18 | High Point (258) | 61 | 57 | UNC-Asheville (302) | Final | W | 4 |
| 20 | 2022-01-22 | Hampton (229) | 45 | 71 | High Point (258) | Final | W | 26 |
| 21 | 2022-01-25 | Longwood (217) | 77 | 64 | High Point (238) | Final | L | -13 |
| 22 | 2022-01-29 | High Point (238) | 57 | 47 | Presbyterian (280) | Final | W | 10 |
| 23 | 2022-02-02 | High Point (244) | 72 | 53 | North Carolina A&T (239) | Final | W | 19 |
| 24 | 2022-02-05 | Winthrop (276) | 44 | 86 | High Point (103) | Final | W | 42 |
| 25 | 2022-02-07 | Radford (174) | 49 | 64 | High Point (103) | Final | W | 15 |
| 26 | 2022-02-09 | High Point (103) | 65 | 57 | Radford (174) | Final | W | 8 |
| 27 | 2022-02-12 | South Carolina Upstate (169) | 59 | 75 | High Point (229) | Final | W | 16 |
| 28 | 2022-02-15 | High Point (209) | 53 | 62 | Gardner-Webb (260) | Final | L | -9 |
| 29 | 2022-02-17 | High Point (209) | 69 | 60 | Charleston Southern (355) | Final | W | 9 |
| 30 | 2022-02-19 | Charleston Southern (355) | 50 | 71 | High Point (209) | Final | W | 21 |
| 31 | 2022-02-21 | High Point (209) | 58 | 42 | Winthrop (352) | Final | W | 16 |
| 32 | 2022-02-23 | UNC-Asheville (335) | 62 | 74 | High Point (219) | Final | W | 12 |
| 33 | 2022-02-26 | High Point (219) | 53 | 60 | Campbell (177) | Final/OT | L | -7 |
| 34 | 2022-03-01 | Charleston Southern (355) | 34 | 54 | High Point (221) | Final | W | 20 |
| 35 | 2022-03-03 | High Point (221) | 53 | 55 | Gardner-Webb (246) | Final | L | -2 |