NCAA Women's Basketball Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-10 | Mount Olive | 65 | 74 | UNC-Wilmington (259) | Final | W | 9 |
| 2 | 2021-11-14 | UNC-Wilmington (259) | 45 | 87 | Duke (73) | Final | L | -42 |
| 3 | 2021-11-18 | UNC-Wilmington (324) | 66 | 108 | Maryland (18) | Final | L | -42 |
| 4 | 2021-11-20 | Coastal Carolina (59) | 73 | 62 | UNC-Wilmington (264) | Final | L | -11 |
| 5 | 2021-11-23 | UNC-Wilmington (324) | 42 | 53 | Campbell (181) | Final | L | -11 |
| 6 | 2021-11-27 | Radford (301) | 51 | 50 | UNC-Wilmington (290) | Final | L | -1 |
| 7 | 2021-12-01 | UNC-Wilmington (326) | 55 | 48 | Winthrop (356) | Final | W | 7 |
| 8 | 2021-12-16 | UNC-Wilmington (312) | 56 | 67 | Norfolk State (258) | Final | L | -11 |
| 9 | 2021-12-19 | East Carolina (106) | 79 | 50 | UNC-Wilmington (324) | Final | L | -29 |
| 10 | 2021-12-22 | UNC-Wilmington (329) | 45 | 42 | UNC-Greensboro (290) | Final | W | 3 |
| 11 | 2021-12-28 | UNC-Wilmington (324) | 0 | 0 | Mercer (245) | Cancelled | - | - |
| 12 | 2021-12-31 | UNC-Wilmington (324) | 0 | 0 | Hofstra (263) | Postponed | - | - |
| 13 | 2022-01-02 | UNC-Wilmington (324) | 0 | 0 | Northeastern (307) | Postponed | - | - |
| 14 | 2022-01-05 | UNC-Wilmington (324) | 67 | 77 | Northeastern (307) | Final | L | -10 |
| 15 | 2022-01-07 | Delaware (149) | 0 | 0 | UNC-Wilmington (318) | Postponed | - | - |
| 16 | 2022-01-09 | Drexel (168) | 71 | 68 | UNC-Wilmington (324) | Final/OT | L | -3 |
| 17 | 2022-01-14 | UNC-Wilmington (319) | 0 | 0 | William & Mary (265) | Postponed | - | - |
| 18 | 2022-01-16 | UNC-Wilmington (324) | 0 | 0 | Elon (233) | Postponed | - | - |
| 19 | 2022-01-21 | James Madison (146) | 57 | 56 | UNC-Wilmington (320) | Final | L | -1 |
| 20 | 2022-01-23 | Towson (199) | 72 | 49 | UNC-Wilmington (324) | Final | L | -23 |
| 21 | 2022-01-26 | Delaware (110) | 78 | 69 | UNC-Wilmington (319) | Final | L | -9 |
| 22 | 2022-01-30 | UNC-Wilmington (319) | 59 | 87 | Charleston (168) | Final | L | -28 |
| 23 | 2022-02-01 | UNC-Wilmington (321) | 40 | 56 | Hofstra (310) | Final | L | -16 |
| 24 | 2022-02-04 | UNC-Wilmington (321) | 39 | 72 | Drexel (58) | Final | L | -33 |
| 25 | 2022-02-06 | UNC-Wilmington (321) | 62 | 77 | Delaware (94) | Final | L | -15 |
| 26 | 2022-02-11 | Elon (159) | 69 | 59 | UNC-Wilmington (328) | Final | L | -10 |
| 27 | 2022-02-13 | William & Mary (282) | 65 | 63 | UNC-Wilmington (328) | Final | L | -2 |
| 28 | 2022-02-16 | UNC-Wilmington (324) | 59 | 69 | William & Mary (210) | Final | L | -10 |
| 29 | 2022-02-18 | UNC-Wilmington (329) | 51 | 67 | Towson (66) | Final | L | -16 |
| 30 | 2022-02-20 | UNC-Wilmington (329) | 51 | 73 | James Madison (155) | Final | L | -22 |
| 31 | 2022-02-23 | UNC-Wilmington (332) | 43 | 64 | Elon (128) | Final | L | -21 |
| 32 | 2022-02-27 | Charleston (174) | 87 | 56 | UNC-Wilmington (332) | Final | L | -31 |
| 33 | 2022-03-03 | Northeastern (171) | 63 | 48 | UNC-Wilmington (334) | Final | L | -15 |
| 34 | 2022-03-05 | Hofstra (286) | 67 | 52 | UNC-Wilmington (334) | Final | L | -15 |
| 35 | 2022-03-10 | UNC-Wilmington (336) | 45 | 46 | Hofstra (287) | Final | L | -1 |