NCAA Women's Basketball Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Winthrop (330) | 39 | 95 | Duke (73) | Final | L | -56 |
| 2 | 2021-11-13 | Winthrop (330) | 45 | 67 | Iona (281) | Final | L | -22 |
| 3 | 2021-11-18 | Winthrop (276) | 39 | 69 | UNC-Greensboro (254) | Final | L | -30 |
| 4 | 2021-11-21 | Winthrop (317) | 47 | 92 | Kentucky (104) | Final | L | -45 |
| 5 | 2021-11-24 | Coker | 51 | 44 | Winthrop (348) | Final | L | -7 |
| 6 | 2021-11-27 | North Carolina-Pembroke | 65 | 45 | Winthrop (348) | Final | L | -20 |
| 7 | 2021-12-01 | UNC-Wilmington (326) | 55 | 48 | Winthrop (356) | Final | L | -7 |
| 8 | 2021-12-04 | Western Carolina (353) | 55 | 71 | Winthrop (276) | Final | W | 16 |
| 9 | 2021-12-12 | Claflin | 56 | 62 | Winthrop (355) | Final | W | 6 |
| 10 | 2021-12-16 | Winthrop (354) | 43 | 68 | Coppin State (202) | Final | L | -25 |
| 11 | 2021-12-19 | Winthrop (276) | 42 | 78 | Charlotte (167) | Final | L | -36 |
| 12 | 2021-12-20 | Winthrop (354) | 0 | 0 | Alabama (43) | Cancelled | - | - |
| 13 | 2021-12-29 | Charleston Southern (356) | 67 | 54 | Winthrop (355) | Final | L | -13 |
| 14 | 2022-01-01 | Winthrop (355) | 0 | 0 | Radford (281) | Postponed | - | - |
| 15 | 2022-01-05 | South Carolina Upstate (315) | 0 | 0 | Winthrop (276) | Postponed | - | - |
| 16 | 2022-01-08 | Winthrop | Longwood | Postponed | - | - | ||
| 17 | 2022-01-11 | High Point (283) | 0 | 0 | Winthrop (356) | Postponed | - | - |
| 18 | 2022-01-15 | Gardner-Webb (289) | 77 | 51 | Winthrop (356) | Final | L | -26 |
| 19 | 2022-01-19 | Campbell (181) | 77 | 54 | Winthrop (276) | Final | L | -23 |
| 20 | 2022-01-22 | Winthrop (356) | 64 | 87 | North Carolina A&T (285) | Final | L | -23 |
| 21 | 2022-01-23 | Winthrop (276) | 58 | 85 | Longwood (171) | Final | L | -27 |
| 22 | 2022-01-26 | Winthrop (356) | 64 | 80 | Hampton (254) | Final | L | -16 |
| 23 | 2022-01-29 | UNC-Asheville (310) | 54 | 75 | Winthrop (356) | Final | W | 21 |
| 24 | 2022-02-01 | Presbyterian (291) | 42 | 58 | Winthrop (354) | Final | W | 16 |
| 25 | 2022-02-05 | Winthrop (276) | 44 | 86 | High Point (103) | Final | L | -42 |
| 26 | 2022-02-08 | South Carolina Upstate (315) | 73 | 43 | Winthrop (276) | Final | L | -30 |
| 27 | 2022-02-09 | Winthrop (276) | 47 | 59 | South Carolina Upstate (315) | Final | L | -12 |
| 28 | 2022-02-12 | Longwood (215) | 78 | 56 | Winthrop (351) | Final | L | -22 |
| 29 | 2022-02-15 | Winthrop (352) | 56 | 43 | Charleston Southern (355) | Final | W | 13 |
| 30 | 2022-02-17 | Winthrop (352) | 50 | 67 | Radford (334) | Final | L | -17 |
| 31 | 2022-02-19 | Radford (334) | 47 | 62 | Winthrop (352) | Final | W | 15 |
| 32 | 2022-02-21 | High Point (209) | 58 | 42 | Winthrop (352) | Final | L | -16 |
| 33 | 2022-02-23 | Winthrop (349) | 35 | 78 | Campbell (177) | Final | L | -43 |
| 34 | 2022-02-26 | Winthrop (349) | 51 | 80 | Gardner-Webb (242) | Final | L | -29 |
| 35 | 2022-03-01 | Winthrop (350) | 60 | 65 | Presbyterian (305) | Final | L | -5 |