NCAA Women's Basketball Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Charleston (250) | 80 | 48 | Wofford (228) | Final | W | 32 |
| 2 | 2021-11-12 | Pfeiffer | 52 | 113 | Charleston (90) | Final | W | 61 |
| 3 | 2021-11-19 | Charleston (96) | 66 | 62 | Norfolk State (174) | Final | W | 4 |
| 4 | 2021-11-23 | Tarleton State (240) | 69 | 59 | Charleston (90) | Final | L | -10 |
| 5 | 2021-11-27 | North Florida (112) | 86 | 76 | Charleston (69) | Final | L | -10 |
| 6 | 2021-11-30 | Georgia Southern (190) | 85 | 65 | Charleston (186) | Final | L | -20 |
| 7 | 2021-12-02 | Charleston (186) | 96 | 60 | Charleston Southern (355) | Final | W | 36 |
| 8 | 2021-12-07 | Charleston (219) | 75 | 68 | UNC-Greensboro (275) | Final | W | 7 |
| 9 | 2021-12-15 | Agnes Scott | 25 | 102 | Charleston (163) | Final | W | 77 |
| 10 | 2021-12-18 | Charleston (90) | 77 | 59 | Radford (174) | Final | W | 18 |
| 11 | 2021-12-19 | Florida A&M (338) | 60 | 83 | Charleston (90) | Final | W | 23 |
| 12 | 2021-12-31 | Charleston (90) | 0 | 0 | Northeastern (307) | Postponed | - | - |
| 13 | 2022-01-02 | Charleston (90) | 0 | 0 | Hofstra (263) | Postponed | - | - |
| 14 | 2022-01-07 | Drexel (99) | 61 | 60 | Charleston (165) | Final | L | -1 |
| 15 | 2022-01-09 | Delaware (241) | 86 | 84 | Charleston (90) | Final/OT | L | -2 |
| 16 | 2022-01-14 | Charleston (188) | 60 | 65 | Elon (106) | Final | L | -5 |
| 17 | 2022-01-16 | Charleston (90) | 87 | 71 | William & Mary (210) | Final | W | 16 |
| 18 | 2022-01-21 | Towson (45) | 72 | 88 | Charleston (180) | Final | W | 16 |
| 19 | 2022-01-23 | James Madison (48) | 64 | 55 | Charleston (90) | Final | L | -9 |
| 20 | 2022-01-26 | Charleston (168) | 70 | 81 | Northeastern (149) | Final | L | -11 |
| 21 | 2022-01-30 | UNC-Wilmington (319) | 59 | 87 | Charleston (168) | Final | W | 28 |
| 22 | 2022-02-04 | Charleston (174) | 79 | 103 | Delaware (94) | Final | L | -24 |
| 23 | 2022-02-06 | Charleston (174) | 74 | 73 | Drexel (58) | Final | W | 1 |
| 24 | 2022-02-11 | William & Mary (282) | 59 | 61 | Charleston (174) | Final | W | 2 |
| 25 | 2022-02-13 | Elon (159) | 71 | 66 | Charleston (174) | Final/OT | L | -5 |
| 26 | 2022-02-18 | Charleston (179) | 71 | 69 | James Madison (155) | Final | W | 2 |
| 27 | 2022-02-20 | Charleston (179) | 57 | 84 | Towson (66) | Final | L | -27 |
| 28 | 2022-02-23 | Charleston (174) | 61 | 73 | Hofstra (294) | Final | L | -12 |
| 29 | 2022-02-27 | Charleston (174) | 87 | 56 | UNC-Wilmington (332) | Final | W | 31 |
| 30 | 2022-03-03 | Hofstra (286) | 35 | 75 | Charleston (186) | Final | W | 40 |
| 31 | 2022-03-05 | Northeastern (171) | 64 | 73 | Charleston (186) | Final | W | 9 |
| 32 | 2022-03-11 | Charleston (172) | 70 | 59 | Elon (128) | Final | W | 11 |
| 33 | 2022-03-12 | Charleston (172) | 65 | 71 | Drexel (64) | Final | L | -6 |