NCAA Women's Basketball Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Northern Iowa (92) | 63 | 54 | Saint Louis (79) | Final | L | -9 |
| 2 | 2021-11-14 | Indiana State (282) | 58 | 65 | Saint Louis (79) | Final | W | 7 |
| 3 | 2021-11-17 | Missouri (75) | 69 | 53 | Saint Louis (187) | Final | L | -16 |
| 4 | 2021-11-21 | Saint Louis (187) | 50 | 79 | Kansas (42) | Final | L | -29 |
| 5 | 2021-11-26 | Saint Louis (206) | 54 | 69 | Florida (55) | Final | L | -15 |
| 6 | 2021-11-27 | Saint Louis (221) | 65 | 73 | Florida Gulf Coast (10) | Final | L | -8 |
| 7 | 2021-12-03 | Saint Louis (226) | 83 | 54 | Southeast Missouri State (298) | Final | W | 29 |
| 8 | 2021-12-05 | Saint Louis (226) | 59 | 54 | Tennessee-Martin (148) | Final | W | 5 |
| 9 | 2021-12-09 | Saint Louis (154) | 57 | 63 | SIU-Edwardsville (169) | Final | L | -6 |
| 10 | 2021-12-11 | Northern Kentucky (141) | 80 | 69 | Saint Louis (154) | Final | L | -11 |
| 11 | 2021-12-18 | Saint Louis (206) | 75 | 47 | Illinois-Chicago (201) | Final | W | 28 |
| 12 | 2021-12-20 | Saint Louis (199) | 66 | 77 | Illinois State (272) | Final | L | -11 |
| 13 | 2021-12-28 | Saint Louis (206) | 0 | 0 | Bradley (155) | Cancelled | - | - |
| 14 | 2022-01-01 | Saint Louis (221) | 0 | 0 | George Washington (148) | Postponed | - | - |
| 15 | 2022-01-05 | Saint Louis (206) | 0 | 0 | Fordham (261) | Postponed | - | - |
| 16 | 2022-01-09 | Virginia Commonwealth | Saint Louis | Postponed | - | - | ||
| 17 | 2022-01-16 | Saint Louis (206) | 59 | 77 | Dayton (141) | Final | L | -18 |
| 18 | 2022-01-19 | St. Bonaventure (195) | 75 | 77 | Saint Louis (206) | Final/OT | W | 2 |
| 19 | 2022-01-22 | Duquesne (205) | 71 | 62 | Saint Louis (219) | Final | L | -9 |
| 20 | 2022-01-26 | Saint Louis (210) | 60 | 55 | Virginia Commonwealth (87) | Final | W | 5 |
| 21 | 2022-01-30 | Richmond (130) | 61 | 54 | Saint Louis (210) | Final | L | -7 |
| 22 | 2022-02-02 | Saint Louis (201) | 52 | 60 | Rhode Island (45) | Final | L | -8 |
| 23 | 2022-02-05 | Saint Louis (206) | 66 | 69 | Massachusetts (95) | Final | L | -3 |
| 24 | 2022-02-09 | Dayton (141) | 69 | 54 | Saint Louis (206) | Final | L | -15 |
| 25 | 2022-02-12 | Davidson (130) | 51 | 54 | Saint Louis (195) | Final | W | 3 |
| 26 | 2022-02-14 | Saint Louis (195) | 41 | 63 | George Washington (222) | Final | L | -22 |
| 27 | 2022-02-16 | Saint Joseph's (92) | 46 | 51 | Saint Louis (206) | Final | W | 5 |
| 28 | 2022-02-19 | Saint Louis (198) | 65 | 73 | La Salle (156) | Final | L | -8 |
| 29 | 2022-02-23 | Saint Louis (196) | 58 | 35 | George Mason (238) | Final | W | 23 |
| 30 | 2022-02-26 | Massachusetts (49) | 74 | 62 | Saint Louis (196) | Final | L | -12 |
| 31 | 2022-03-02 | George Mason (236) | 65 | 50 | Saint Louis (191) | Final | L | -15 |