NCAA Women's Basketball Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-14 | Mississippi Valley State (332) | 44 | 94 | Ole Miss (50) | Final | L | -50 |
| 2 | 2021-11-19 | Mississippi Valley State (324) | 62 | 76 | UAB (125) | Final | L | -14 |
| 3 | 2021-11-23 | Murray State (52) | 74 | 50 | Mississippi Valley State (342) | Final | L | -24 |
| 4 | 2021-11-26 | Southeast Missouri State (243) | 82 | 76 | Mississippi Valley State (342) | Final | L | -6 |
| 5 | 2021-11-27 | Mississippi Valley State (311) | 53 | 72 | Southern Miss (188) | Final | L | -19 |
| 6 | 2021-12-05 | Mississippi Valley State (349) | 56 | 69 | Louisiana Tech (158) | Final | L | -13 |
| 7 | 2021-12-11 | Northwestern State (246) | 78 | 71 | Mississippi Valley State (345) | Final/OT | L | -7 |
| 8 | 2021-12-14 | Mississippi Valley State (345) | 47 | 81 | Arkansas State (255) | Final | L | -34 |
| 9 | 2021-12-20 | Mississippi Valley State (346) | 73 | 72 | Louisiana-Monroe (325) | Final/OT | W | 1 |
| 10 | 2022-01-03 | Alabama State (279) | 0 | 0 | Mississippi Valley State (339) | Forfeit | - | - |
| 11 | 2022-01-05 | Alabama A&M (196) | 65 | 56 | Mississippi Valley State (342) | Final | L | -9 |
| 12 | 2022-01-08 | Mississippi Valley State (342) | 77 | 84 | Prairie View A&M (361) | Final | L | -7 |
| 13 | 2022-01-10 | Mississippi Valley State (342) | 66 | 100 | Texas Southern (337) | Final | L | -34 |
| 14 | 2022-01-15 | Bethune-Cookman (347) | 78 | 74 | Mississippi Valley State (350) | Final | L | -4 |
| 15 | 2022-01-17 | Florida A&M (341) | 62 | 78 | Mississippi Valley State (350) | Final | W | 16 |
| 16 | 2022-01-22 | Mississippi Valley State (349) | 61 | 76 | Grambling (316) | Final | L | -15 |
| 17 | 2022-01-24 | Mississippi Valley State (349) | 58 | 67 | Southern (269) | Final | L | -9 |
| 18 | 2022-01-29 | Arkansas-Pine Bluff (264) | 75 | 63 | Mississippi Valley State (349) | Final | L | -12 |
| 19 | 2022-02-05 | Jackson State (314) | 88 | 54 | Mississippi Valley State (342) | Final | L | -34 |
| 20 | 2022-02-07 | Alcorn State (277) | 76 | 93 | Mississippi Valley State (342) | Final | W | 17 |
| 21 | 2022-02-12 | Mississippi Valley State (349) | 47 | 53 | Alabama A&M (287) | Final | L | -6 |
| 22 | 2022-02-14 | Mississippi Valley State (349) | 77 | 90 | Alabama State (296) | Final | L | -13 |
| 23 | 2022-02-19 | Texas Southern (290) | 82 | 77 | Mississippi Valley State (348) | Final | L | -5 |
| 24 | 2022-02-21 | Prairie View A&M (307) | 70 | 60 | Mississippi Valley State (348) | Final | L | -10 |
| 25 | 2022-02-26 | Mississippi Valley State (348) | 64 | 78 | Arkansas-Pine Bluff (284) | Final | L | -14 |
| 26 | 2022-03-03 | Mississippi Valley State (349) | 62 | 47 | Alcorn State (352) | Final | W | 15 |
| 27 | 2022-03-05 | Mississippi Valley State (349) | 57 | 118 | Jackson State (107) | Final | L | -61 |