NCAA Women's Basketball Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Green Bay (107) | 49 | 70 | South Dakota State (29) | Final | W | 21 |
| 2 | 2021-11-12 | South Dakota State (42) | 71 | 76 | Mississippi State (51) | Final | L | -5 |
| 3 | 2021-11-15 | South Dakota State (29) | 56 | 75 | Iowa State (32) | Final | L | -19 |
| 4 | 2021-11-18 | Montana State (76) | 49 | 78 | South Dakota State (42) | Final | W | 29 |
| 5 | 2021-11-21 | South Dakota State (179) | 55 | 67 | Creighton (213) | Final | L | -12 |
| 6 | 2021-11-26 | Massachusetts (95) | 81 | 63 | South Dakota State (42) | Final | L | -18 |
| 7 | 2021-11-27 | UCLA (77) | 66 | 76 | South Dakota State (181) | Final | W | 10 |
| 8 | 2021-11-28 | Charlotte (205) | 0 | 0 | South Dakota State (181) | Cancelled | - | - |
| 9 | 2021-12-04 | South Dakota State (42) | 50 | 59 | Northern Iowa (132) | Final | L | -9 |
| 10 | 2021-12-06 | Missouri State (45) | 55 | 52 | South Dakota State (117) | Final | L | -3 |
| 11 | 2021-12-11 | Kansas State (22) | 79 | 73 | South Dakota State (126) | Final | L | -6 |
| 12 | 2021-12-15 | Dakota Wesleyan | 43 | 90 | South Dakota State (124) | Final | W | 47 |
| 13 | 2021-12-20 | South Dakota State (124) | 85 | 78 | UMKC (49) | Final | W | 7 |
| 14 | 2021-12-22 | South Dakota State (107) | 71 | 51 | Oral Roberts (185) | Final | W | 20 |
| 15 | 2021-12-30 | North Dakota State (190) | 60 | 77 | South Dakota State (104) | Final | W | 17 |
| 16 | 2022-01-01 | North Dakota (256) | 54 | 72 | South Dakota State (104) | Final | W | 18 |
| 17 | 2022-01-08 | South Dakota State (42) | 42 | 65 | South Dakota (112) | Final | L | -23 |
| 18 | 2022-01-13 | South Dakota State (42) | 72 | 49 | Nebraska-Omaha (345) | Final | W | 23 |
| 19 | 2022-01-15 | South Dakota State (94) | 87 | 43 | Denver (306) | Final | W | 44 |
| 20 | 2022-01-20 | St. Thomas (292) | 47 | 88 | South Dakota State (81) | Final | W | 41 |
| 21 | 2022-01-22 | Western Illinois (177) | 50 | 114 | South Dakota State (81) | Final | W | 64 |
| 22 | 2022-01-27 | South Dakota State (42) | 75 | 49 | North Dakota (332) | Final | W | 26 |
| 23 | 2022-01-29 | South Dakota State (70) | 76 | 60 | North Dakota State (216) | Final | W | 16 |
| 24 | 2022-02-05 | South Dakota (112) | 65 | 75 | South Dakota State (42) | Final | W | 10 |
| 25 | 2022-02-10 | Denver (269) | 52 | 79 | South Dakota State (42) | Final | W | 27 |
| 26 | 2022-02-12 | Nebraska-Omaha (275) | 62 | 77 | South Dakota State (57) | Final | W | 15 |
| 27 | 2022-02-17 | South Dakota State (58) | 84 | 54 | Western Illinois (204) | Final | W | 30 |
| 28 | 2022-02-19 | South Dakota State (58) | 83 | 42 | St. Thomas (302) | Final | W | 41 |
| 29 | 2022-02-24 | Oral Roberts (181) | 48 | 84 | South Dakota State (58) | Final | W | 36 |
| 30 | 2022-02-26 | UMKC (93) | 62 | 94 | South Dakota State (58) | Final | W | 32 |
| 31 | 2022-03-05 | Denver (280) | 59 | 86 | South Dakota State (52) | Final | W | 27 |
| 32 | 2022-03-07 | Oral Roberts (189) | 53 | 72 | South Dakota State (52) | Final | W | 19 |
| 33 | 2022-03-08 | South Dakota (40) | 56 | 45 | South Dakota State (52) | Final | L | -11 |
| 34 | 2022-03-17 | Ohio (143) | 57 | 87 | South Dakota State (53) | Final | W | 30 |
| 35 | 2022-03-20 | Minnesota (101) | 57 | 78 | South Dakota State (53) | Final | W | 21 |
| 36 | 2022-03-24 | Drake (102) | 66 | 84 | South Dakota State (53) | Final | W | 18 |
| 37 | 2022-03-27 | Alabama (54) | 73 | 78 | South Dakota State (53) | Final | W | 5 |
| 38 | 2022-03-31 | UCLA (65) | 59 | 62 | South Dakota State (53) | Final | W | 3 |
| 39 | 2022-04-02 | Seton Hall (77) | 50 | 82 | South Dakota State (53) | Final | W | 32 |