NCAA Women's Basketball Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Alabama State (120) | 62 | 91 | Mississippi State (44) | Final | W | 29 |
| 2 | 2021-11-12 | South Dakota State (42) | 71 | 76 | Mississippi State (51) | Final | W | 5 |
| 3 | 2021-11-14 | Alcorn State (294) | 63 | 86 | Mississippi State (44) | Final | W | 23 |
| 4 | 2021-11-22 | Bethune-Cookman (290) | 53 | 94 | Mississippi State (43) | Final | W | 41 |
| 5 | 2021-11-25 | Dayton (141) | 54 | 65 | Mississippi State (51) | Final | W | 11 |
| 6 | 2021-11-27 | Mississippi State (60) | 48 | 64 | Michigan (28) | Final | L | -16 |
| 7 | 2021-12-01 | McNeese State (274) | 55 | 102 | Mississippi State (50) | Final | W | 47 |
| 8 | 2021-12-04 | Mississippi State (51) | 63 | 94 | Oklahoma (10) | Final | L | -31 |
| 9 | 2021-12-12 | Mississippi State (71) | 54 | 37 | Tennessee-Martin (170) | Final | W | 17 |
| 10 | 2021-12-18 | Troy (67) | 73 | 66 | Mississippi State (51) | Final | L | -7 |
| 11 | 2021-12-19 | Jackson State (314) | 66 | 74 | Mississippi State (51) | Final | W | 8 |
| 12 | 2021-12-20 | South Carolina State (353) | 47 | 85 | Mississippi State (73) | Final | W | 38 |
| 13 | 2021-12-30 | Florida (69) | 0 | 0 | Mississippi State (78) | Postponed | - | - |
| 14 | 2022-01-02 | Mississippi State (51) | 68 | 80 | South Carolina (3) | Final | L | -12 |
| 15 | 2022-01-03 | Mississippi State (78) | 0 | 0 | Kentucky (53) | Postponed | - | - |
| 16 | 2022-01-06 | Mississippi State (76) | 65 | 62 | Alabama (40) | Final | W | 3 |
| 17 | 2022-01-09 | Vanderbilt (7) | 63 | 70 | Mississippi State (51) | Final | W | 7 |
| 18 | 2022-01-13 | Mississippi State (51) | 0 | 0 | Kentucky (16) | Postponed | - | - |
| 19 | 2022-01-16 | Mississippi State (51) | 71 | 86 | Ole Miss (22) | Final | L | -15 |
| 20 | 2022-01-20 | Georgia (13) | 66 | 63 | Mississippi State (55) | Final | L | -3 |
| 21 | 2022-01-23 | Mississippi State (51) | 54 | 74 | Arkansas (114) | Final | L | -20 |
| 22 | 2022-01-27 | Missouri (71) | 62 | 77 | Mississippi State (51) | Final | W | 15 |
| 23 | 2022-01-30 | Texas A&M (47) | 58 | 78 | Mississippi State (59) | Final | W | 20 |
| 24 | 2022-02-03 | Mississippi State (47) | 70 | 65 | Auburn (112) | Final | W | 5 |
| 25 | 2022-02-10 | Florida (55) | 73 | 64 | Mississippi State (51) | Final | L | -9 |
| 26 | 2022-02-13 | Ole Miss (21) | 59 | 70 | Mississippi State (45) | Final | W | 11 |
| 27 | 2022-02-15 | Mississippi State (46) | 74 | 81 | Kentucky (67) | Final | L | -7 |
| 28 | 2022-02-17 | LSU (9) | 71 | 59 | Mississippi State (46) | Final | L | -12 |
| 29 | 2022-02-20 | Mississippi State (46) | 66 | 76 | Missouri (48) | Final | L | -10 |
| 30 | 2022-02-24 | Mississippi State (53) | 64 | 86 | Tennessee (11) | Final | L | -22 |
| 31 | 2022-02-27 | Arkansas (36) | 87 | 79 | Mississippi State (53) | Final | L | -8 |
| 32 | 2022-03-03 | Mississippi State (59) | 67 | 83 | Kentucky (42) | Final | L | -16 |