NCAA Women's Basketball Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-10 | St. Thomas | 51 | 67 | Wisconsin (204) | Final | L | -16 |
| 2 | 2021-11-13 | Illinois State (82) | 70 | 55 | St. Thomas | Final | L | -15 |
| 3 | 2021-11-18 | St. Thomas (218) | 65 | 50 | South Carolina State (355) | Final | W | 15 |
| 4 | 2021-11-20 | St. Thomas (351) | 62 | 82 | Presbyterian (340) | Final | L | -20 |
| 5 | 2021-11-26 | St. Thomas (218) | 51 | 63 | Cal Poly (350) | Final | L | -12 |
| 6 | 2021-11-27 | St. Thomas (347) | 54 | 81 | North Texas (162) | Final | L | -27 |
| 7 | 2021-12-01 | Northern Iowa (97) | 102 | 62 | St. Thomas (350) | Final | L | -40 |
| 8 | 2021-12-04 | St. Thomas (218) | 62 | 57 | Chicago State (346) | Final | W | 5 |
| 9 | 2021-12-11 | Idaho State (261) | 67 | 57 | St. Thomas (338) | Final | L | -10 |
| 10 | 2021-12-15 | Northland | 19 | 92 | St. Thomas (328) | Final | W | 73 |
| 11 | 2021-12-20 | Nebraska-Omaha (194) | 61 | 55 | St. Thomas (328) | Final | L | -6 |
| 12 | 2021-12-22 | Denver (276) | 48 | 56 | St. Thomas (328) | Final | W | 8 |
| 13 | 2021-12-29 | Upper Iowa | 0 | 0 | St. Thomas (317) | Postponed | - | - |
| 14 | 2022-01-01 | St. Thomas (317) | 66 | 64 | Western Illinois (105) | Final/2OT | W | 2 |
| 15 | 2022-01-06 | St. Thomas (301) | 0 | 0 | Oral Roberts (183) | Postponed | - | - |
| 16 | 2022-01-13 | North Dakota State (59) | 62 | 73 | St. Thomas (218) | Final | W | 11 |
| 17 | 2022-01-15 | North Dakota (249) | 66 | 55 | St. Thomas (298) | Final | L | -11 |
| 18 | 2022-01-17 | St. Thomas (298) | 44 | 72 | Oral Roberts (184) | Final | L | -28 |
| 19 | 2022-01-20 | St. Thomas (292) | 47 | 88 | South Dakota State (81) | Final | L | -41 |
| 20 | 2022-01-22 | St. Thomas (292) | 43 | 70 | South Dakota (37) | Final | L | -27 |
| 21 | 2022-01-29 | Western Illinois (194) | 82 | 67 | St. Thomas (296) | Final | L | -15 |
| 22 | 2022-02-03 | UMKC (97) | 62 | 57 | St. Thomas (298) | Final | L | -5 |
| 23 | 2022-02-05 | Oral Roberts (203) | 73 | 67 | St. Thomas (218) | Final/OT | L | -6 |
| 24 | 2022-02-10 | St. Thomas (218) | 61 | 74 | North Dakota (332) | Final | L | -13 |
| 25 | 2022-02-12 | St. Thomas (297) | 60 | 69 | North Dakota State (227) | Final | L | -9 |
| 26 | 2022-02-14 | St. Thomas (297) | 53 | 69 | UMKC (96) | Final | L | -16 |
| 27 | 2022-02-17 | South Dakota (45) | 73 | 46 | St. Thomas (302) | Final | L | -27 |
| 28 | 2022-02-19 | South Dakota State (58) | 83 | 42 | St. Thomas (302) | Final | L | -41 |
| 29 | 2022-02-24 | St. Thomas (305) | 63 | 66 | Denver (288) | Final | L | -3 |
| 30 | 2022-02-26 | St. Thomas (305) | 61 | 56 | Nebraska-Omaha (270) | Final | W | 5 |