NCAA Women's Basketball Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Gardner-Webb (268) | 59 | 75 | Vanderbilt (128) | Final | W | 16 |
| 2 | 2021-11-12 | Little Rock (228) | 56 | 40 | Vanderbilt (7) | Final | L | -16 |
| 3 | 2021-11-15 | Vanderbilt (128) | 46 | 55 | Middle Tennessee (81) | Final | L | -9 |
| 4 | 2021-11-18 | Tennessee Tech (222) | 55 | 75 | Vanderbilt (7) | Final | W | 20 |
| 5 | 2021-11-21 | Jacksonville State (258) | 61 | 71 | Vanderbilt (256) | Final | W | 10 |
| 6 | 2021-11-25 | Vanderbilt (7) | 46 | 48 | Arizona (123) | Final | L | -2 |
| 7 | 2021-11-26 | Rutgers (158) | 40 | 51 | Vanderbilt (7) | Final | W | 11 |
| 8 | 2021-11-27 | Vanderbilt (124) | 74 | 91 | DePaul (48) | Final | L | -17 |
| 9 | 2021-11-30 | Chattanooga (332) | 61 | 91 | Vanderbilt (111) | Final | W | 30 |
| 10 | 2021-12-05 | Vanderbilt (111) | 67 | 74 | Kansas (27) | Final | L | -7 |
| 11 | 2021-12-08 | Albany (232) | 41 | 52 | Vanderbilt (111) | Final | W | 11 |
| 12 | 2021-12-18 | Presbyterian (357) | 57 | 81 | Vanderbilt (7) | Final | W | 24 |
| 13 | 2021-12-21 | Vanderbilt (101) | 64 | 45 | Saint Joseph's (182) | Final | W | 19 |
| 14 | 2021-12-28 | Alabama State (288) | 42 | 94 | Vanderbilt (7) | Final | W | 52 |
| 15 | 2021-12-30 | Vanderbilt (98) | 0 | 0 | Texas A&M (23) | Postponed | - | - |
| 16 | 2022-01-02 | Missouri (71) | 0 | 0 | Vanderbilt (7) | Postponed | - | - |
| 17 | 2022-01-06 | Arkansas (37) | 51 | 54 | Vanderbilt (88) | Final | W | 3 |
| 18 | 2022-01-09 | Vanderbilt (7) | 63 | 70 | Mississippi State (51) | Final | L | -7 |
| 19 | 2022-01-13 | Tennessee (33) | 65 | 51 | Vanderbilt (7) | Final | L | -14 |
| 20 | 2022-01-16 | Vanderbilt (7) | 64 | 82 | LSU (5) | Final | L | -18 |
| 21 | 2022-01-20 | Missouri (42) | 66 | 52 | Vanderbilt (85) | Final | L | -14 |
| 22 | 2022-01-24 | Vanderbilt (85) | 30 | 85 | South Carolina (1) | Final | L | -55 |
| 23 | 2022-01-27 | Kentucky (16) | 57 | 65 | Vanderbilt (7) | Final | W | 8 |
| 24 | 2022-01-30 | Auburn (120) | 66 | 81 | Vanderbilt (92) | Final | W | 15 |
| 25 | 2022-02-03 | Vanderbilt (78) | 56 | 71 | Georgia (14) | Final | L | -15 |
| 26 | 2022-02-06 | Alabama (76) | 77 | 71 | Vanderbilt (78) | Final/OT | L | -6 |
| 27 | 2022-02-10 | Vanderbilt (7) | 58 | 76 | Texas A&M (54) | Final | L | -18 |
| 28 | 2022-02-13 | Vanderbilt (83) | 52 | 66 | Tennessee (8) | Final | L | -14 |
| 29 | 2022-02-17 | Vanderbilt (87) | 65 | 69 | Kentucky (67) | Final | L | -4 |
| 30 | 2022-02-20 | Ole Miss (28) | 57 | 47 | Vanderbilt (87) | Final | L | -10 |
| 31 | 2022-02-24 | Florida (27) | 59 | 63 | Vanderbilt (94) | Final | W | 4 |
| 32 | 2022-02-27 | Vanderbilt (94) | 71 | 77 | Alabama (64) | Final | L | -6 |
| 33 | 2022-03-02 | Vanderbilt (87) | 85 | 69 | Texas A&M (55) | Final | W | 16 |
| 34 | 2022-03-03 | Vanderbilt (87) | 52 | 53 | Florida (33) | Final | L | -1 |
| 35 | 2022-03-17 | Murray State (134) | 47 | 73 | Vanderbilt (81) | Final | W | 26 |
| 36 | 2022-03-21 | Liberty (60) | 45 | 71 | Vanderbilt (81) | Final | W | 26 |
| 37 | 2022-03-24 | Vanderbilt (81) | 53 | 55 | Middle Tennessee (71) | Final | L | -2 |