NCAA Women's Basketball Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-10 | Northeastern (194) | 71 | 45 | Holy Cross (183) | Final | L | -26 |
| 2 | 2021-11-13 | Holy Cross (183) | 50 | 75 | Boston College (94) | Final | L | -25 |
| 3 | 2021-11-16 | Dartmouth (316) | 49 | 77 | Holy Cross (319) | Final | W | 28 |
| 4 | 2021-11-19 | Massachusetts (54) | 61 | 58 | Holy Cross (319) | Final | L | -3 |
| 5 | 2021-11-22 | Connecticut College | 36 | 79 | Holy Cross (319) | Final | W | 43 |
| 6 | 2021-11-28 | Holy Cross (236) | 67 | 49 | Bryant (353) | Final | W | 18 |
| 7 | 2021-12-02 | Rhode Island (28) | 54 | 66 | Holy Cross (210) | Final | W | 12 |
| 8 | 2021-12-05 | Brown (342) | 57 | 55 | Holy Cross (210) | Final | L | -2 |
| 9 | 2021-12-08 | Holy Cross (205) | 50 | 49 | New Hampshire (300) | Final | W | 1 |
| 10 | 2021-12-12 | Stetson (130) | 50 | 65 | Holy Cross (205) | Final | W | 15 |
| 11 | 2021-12-22 | Holy Cross (173) | 56 | 67 | Pittsburgh (66) | Final | L | -11 |
| 12 | 2021-12-29 | Holy Cross (177) | 63 | 53 | Navy (274) | Final | W | 10 |
| 13 | 2022-01-02 | Loyola-Maryland (258) | 0 | 0 | Holy Cross (121) | Postponed | - | - |
| 14 | 2022-01-05 | Holy Cross (121) | 0 | 0 | Lafayette (292) | Postponed | - | - |
| 15 | 2022-01-08 | Lehigh (189) | 53 | 64 | Holy Cross (121) | Final | W | 11 |
| 16 | 2022-01-12 | Holy Cross (121) | 39 | 52 | American (316) | Final | L | -13 |
| 17 | 2022-01-15 | Colgate (340) | 57 | 62 | Holy Cross (146) | Final | W | 5 |
| 18 | 2022-01-17 | Loyola-Maryland (299) | 48 | 63 | Holy Cross (146) | Final | W | 15 |
| 19 | 2022-01-19 | Lafayette (292) | 57 | 63 | Holy Cross (121) | Final | W | 6 |
| 20 | 2022-01-22 | Holy Cross (168) | 63 | 62 | Bucknell (103) | Final/OT | W | 1 |
| 21 | 2022-01-26 | American (157) | 44 | 55 | Holy Cross (142) | Final | W | 11 |
| 22 | 2022-01-28 | Holy Cross (142) | 61 | 67 | Lehigh (122) | Final | L | -6 |
| 23 | 2022-02-03 | Holy Cross (145) | 59 | 50 | Lafayette (274) | Final | W | 9 |
| 24 | 2022-02-05 | Army (109) | 54 | 74 | Holy Cross (121) | Final | W | 20 |
| 25 | 2022-02-09 | Holy Cross (121) | 58 | 49 | Loyola-Maryland (258) | Final | W | 9 |
| 26 | 2022-02-12 | Bucknell (108) | 66 | 49 | Holy Cross (128) | Final | L | -17 |
| 27 | 2022-02-16 | Holy Cross (121) | 56 | 74 | Boston University (284) | Final | L | -18 |
| 28 | 2022-02-19 | Navy (286) | 57 | 63 | Holy Cross (132) | Final | W | 6 |
| 29 | 2022-02-23 | Holy Cross (150) | 62 | 55 | Colgate (319) | Final | W | 7 |
| 30 | 2022-02-26 | Holy Cross (150) | 73 | 59 | Army (203) | Final | W | 14 |
| 31 | 2022-03-02 | Boston University (153) | 48 | 59 | Holy Cross (145) | Final | W | 11 |
| 32 | 2022-03-07 | Navy (290) | 50 | 49 | Holy Cross (145) | Final | L | -1 |
| 33 | 2022-03-16 | Holy Cross (152) | 69 | 80 | Columbia (74) | Final | L | -11 |