NCAA Women's Basketball Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | George Mason (312) | 69 | 67 | Florida International (191) | Final | W | 2 |
| 2 | 2021-11-12 | George Mason (57) | 53 | 51 | Loyola-Maryland (258) | Final | W | 2 |
| 3 | 2021-11-14 | Virginia Tech (36) | 81 | 52 | George Mason (312) | Final | L | -29 |
| 4 | 2021-11-16 | George Mason (115) | 64 | 55 | Charleston Southern (341) | Final | W | 9 |
| 5 | 2021-11-19 | George Mason (115) | 54 | 65 | William & Mary (232) | Final/OT | L | -11 |
| 6 | 2021-11-23 | George Mason (57) | 61 | 69 | American (316) | Final | L | -8 |
| 7 | 2021-11-27 | Bowling Green (194) | 75 | 77 | George Mason (189) | Final/OT | W | 2 |
| 8 | 2021-11-28 | George Mason (189) | 69 | 64 | Navy (208) | Final | W | 5 |
| 9 | 2021-12-01 | Florida (74) | 71 | 75 | George Mason (187) | Final | W | 4 |
| 10 | 2021-12-06 | Norfolk State (260) | 66 | 59 | George Mason (187) | Final | L | -7 |
| 11 | 2021-12-18 | George Mason (57) | 67 | 77 | Bucknell (275) | Final | L | -10 |
| 12 | 2021-12-20 | James Madison (196) | 69 | 61 | George Mason (190) | Final | L | -8 |
| 13 | 2021-12-28 | Coppin State (311) | 0 | 0 | George Mason (57) | Cancelled | - | - |
| 14 | 2022-01-01 | George Mason (204) | 0 | 0 | Massachusetts (36) | Postponed | - | - |
| 15 | 2022-01-04 | La Salle (172) | 0 | 0 | George Mason (201) | Postponed | - | - |
| 16 | 2022-01-08 | George Mason (57) | 0 | 0 | Saint Joseph's (92) | Postponed | - | - |
| 17 | 2022-01-12 | Fordham (261) | 73 | 64 | George Mason (57) | Final | L | -9 |
| 18 | 2022-01-15 | George Mason (209) | 49 | 59 | Rhode Island (71) | Final | L | -10 |
| 19 | 2022-01-19 | Richmond (43) | 78 | 64 | George Mason (57) | Final | L | -14 |
| 20 | 2022-01-21 | La Salle (136) | 63 | 53 | George Mason (212) | Final | L | -10 |
| 21 | 2022-01-23 | St. Bonaventure (195) | 81 | 74 | George Mason (57) | Final | L | -7 |
| 22 | 2022-01-26 | George Mason (243) | 55 | 67 | Duquesne (195) | Final | L | -12 |
| 23 | 2022-01-29 | George Washington (176) | 46 | 52 | George Mason (243) | Final | W | 6 |
| 24 | 2022-02-02 | George Mason (237) | 58 | 50 | Davidson (102) | Final | W | 8 |
| 25 | 2022-02-05 | George Mason (57) | 44 | 84 | Dayton (141) | Final | L | -40 |
| 26 | 2022-02-11 | George Mason (224) | 58 | 87 | Massachusetts (50) | Final | L | -29 |
| 27 | 2022-02-13 | Saint Joseph's (171) | 50 | 45 | George Mason (224) | Final | L | -5 |
| 28 | 2022-02-16 | George Mason (57) | 57 | 65 | George Washington (160) | Final | L | -8 |
| 29 | 2022-02-19 | Virginia Commonwealth (82) | 67 | 56 | George Mason (230) | Final | L | -11 |
| 30 | 2022-02-23 | Saint Louis (196) | 58 | 35 | George Mason (238) | Final | L | -23 |
| 31 | 2022-02-26 | George Mason (238) | 61 | 50 | St. Bonaventure (218) | Final | W | 11 |
| 32 | 2022-03-02 | George Mason (236) | 65 | 50 | Saint Louis (191) | Final | W | 15 |
| 33 | 2022-03-03 | George Mason (236) | 50 | 66 | Fordham (69) | Final | L | -16 |