NCAA Women's Basketball Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Iona (281) | 60 | 56 | Bryant (290) | Final | W | 4 |
| 2 | 2021-11-13 | Winthrop (330) | 45 | 67 | Iona (281) | Final | W | 22 |
| 3 | 2021-11-16 | Iona (90) | 56 | 79 | Massachusetts (54) | Final | L | -23 |
| 4 | 2021-11-20 | Stony Brook (28) | 53 | 46 | Iona (90) | Final | L | -7 |
| 5 | 2021-11-23 | Bucknell (275) | 55 | 48 | Iona (251) | Final | L | -7 |
| 6 | 2021-12-01 | Iona (245) | 0 | 0 | Seton Hall (125) | Postponed | - | - |
| 7 | 2021-12-04 | Wagner (327) | 0 | 0 | Iona (251) | Cancelled | - | - |
| 8 | 2021-12-08 | Iona (228) | 0 | 0 | St. John's (128) | Cancelled | - | - |
| 9 | 2021-12-12 | Iona (228) | 0 | 0 | Sacred Heart (212) | Postponed | - | - |
| 10 | 2021-12-18 | Monmouth (185) | 64 | 55 | Iona (251) | Final | L | -9 |
| 11 | 2021-12-20 | Iona (226) | 49 | 61 | Marist (261) | Final | L | -12 |
| 12 | 2021-12-30 | Iona (276) | 52 | 69 | Fairfield (147) | Final | L | -17 |
| 13 | 2022-01-06 | Siena (352) | 0 | 0 | Iona (291) | Postponed | - | - |
| 14 | 2022-01-10 | Siena (295) | 56 | 51 | Iona (251) | Final | L | -5 |
| 15 | 2022-01-13 | Iona (251) | 59 | 64 | Manhattan (296) | Final | L | -5 |
| 16 | 2022-01-15 | Quinnipiac (160) | 47 | 52 | Iona (314) | Final | W | 5 |
| 17 | 2022-01-20 | Marist (259) | 41 | 49 | Iona (288) | Final | W | 8 |
| 18 | 2022-01-22 | Iona (288) | 53 | 54 | Saint Peter's (265) | Final | L | -1 |
| 19 | 2022-01-27 | Manhattan (296) | 71 | 69 | Iona (251) | Final | L | -2 |
| 20 | 2022-01-29 | Iona (281) | 63 | 40 | Rider (291) | Final | W | 23 |
| 21 | 2022-02-03 | Canisius (336) | 55 | 66 | Iona (272) | Final | W | 11 |
| 22 | 2022-02-05 | Iona (251) | 64 | 57 | Siena (295) | Final | W | 7 |
| 23 | 2022-02-10 | Fairfield (50) | 54 | 29 | Iona (251) | Final | L | -25 |
| 24 | 2022-02-12 | Iona (262) | 49 | 78 | Quinnipiac (162) | Final | L | -29 |
| 25 | 2022-02-17 | Niagara (254) | 59 | 45 | Iona (275) | Final | L | -14 |
| 26 | 2022-02-19 | Saint Peter's (258) | 44 | 63 | Iona (275) | Final | W | 19 |
| 27 | 2022-02-24 | Rider (289) | 58 | 65 | Iona (269) | Final | W | 7 |
| 28 | 2022-02-26 | Iona (269) | 69 | 65 | Monmouth (237) | Final | W | 4 |
| 29 | 2022-03-03 | Iona (262) | 50 | 66 | Niagara (256) | Final/OT | L | -16 |
| 30 | 2022-03-05 | Iona (262) | 62 | 71 | Canisius (336) | Final | L | -9 |
| 31 | 2022-03-08 | Rider (292) | 58 | 74 | Iona (275) | Final | W | 16 |
| 32 | 2022-03-09 | Iona (275) | 56 | 69 | Fairfield (98) | Final | L | -13 |