NCAA Women's Basketball Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Coppin State (335) | 73 | 70 | La Salle (197) | Final | L | -3 |
| 2 | 2021-11-13 | Rider (293) | 58 | 67 | La Salle (197) | Final/OT | W | 9 |
| 3 | 2021-11-17 | La Salle (190) | 65 | 71 | Drexel (151) | Final | L | -6 |
| 4 | 2021-11-20 | Niagara (226) | 71 | 83 | La Salle (190) | Final | W | 12 |
| 5 | 2021-11-23 | Lafayette (292) | 52 | 73 | La Salle (143) | Final | W | 21 |
| 6 | 2021-11-27 | La Salle (195) | 52 | 74 | Kentucky (79) | Final | L | -22 |
| 7 | 2021-11-30 | La Salle (199) | 63 | 49 | Penn (143) | Final | W | 14 |
| 8 | 2021-12-04 | La Salle (143) | 64 | 59 | Saint Francis (359) | Final | W | 5 |
| 9 | 2021-12-08 | Maryland-Eastern Shore (291) | 70 | 77 | La Salle (144) | Final | W | 7 |
| 10 | 2021-12-11 | La Salle (144) | 70 | 83 | St. John's (128) | Final | L | -13 |
| 11 | 2021-12-18 | Sacred Heart (301) | 44 | 72 | La Salle (143) | Final | W | 28 |
| 12 | 2021-12-21 | Villanova (132) | 66 | 56 | La Salle (158) | Final | L | -10 |
| 13 | 2021-12-29 | La Salle (172) | 0 | 0 | Temple (146) | Postponed | - | - |
| 14 | 2022-01-01 | Virginia Commonwealth (88) | 0 | 0 | La Salle (172) | Postponed | - | - |
| 15 | 2022-01-04 | La Salle (172) | 0 | 0 | George Mason (201) | Postponed | - | - |
| 16 | 2022-01-09 | La Salle (143) | 71 | 62 | Fordham (261) | Final | W | 9 |
| 17 | 2022-01-09 | La Salle | Massachusetts | Postponed | - | - | ||
| 18 | 2022-01-12 | Dayton (141) | 65 | 57 | La Salle (143) | Final | L | -8 |
| 19 | 2022-01-17 | La Salle (140) | 69 | 65 | Saint Joseph's (196) | Final | W | 4 |
| 20 | 2022-01-21 | La Salle (136) | 63 | 53 | George Mason (212) | Final | W | 10 |
| 21 | 2022-01-23 | Richmond (43) | 57 | 77 | La Salle (143) | Final | W | 20 |
| 22 | 2022-01-26 | La Salle (124) | 57 | 61 | St. Bonaventure (236) | Final | L | -4 |
| 23 | 2022-01-30 | La Salle (124) | 48 | 67 | Duquesne (195) | Final | L | -19 |
| 24 | 2022-02-02 | Saint Joseph's (189) | 58 | 66 | La Salle (153) | Final | W | 8 |
| 25 | 2022-02-04 | Virginia Commonwealth (99) | 62 | 56 | La Salle (153) | Final | L | -6 |
| 26 | 2022-02-06 | Rhode Island (45) | 66 | 60 | La Salle (153) | Final | L | -6 |
| 27 | 2022-02-13 | La Salle (145) | 58 | 75 | Richmond (154) | Final | L | -17 |
| 28 | 2022-02-16 | Davidson (79) | 68 | 80 | La Salle (143) | Final | W | 12 |
| 29 | 2022-02-19 | Saint Louis (198) | 65 | 73 | La Salle (156) | Final | W | 8 |
| 30 | 2022-02-23 | Duquesne (172) | 66 | 67 | La Salle (135) | Final | W | 1 |
| 31 | 2022-02-26 | La Salle (135) | 62 | 55 | George Washington (191) | Final | W | 7 |
| 32 | 2022-03-03 | George Washington (198) | 64 | 54 | La Salle (122) | Final | L | -10 |