NCAA Women's Basketball Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Maryland-Eastern Shore | 49 | 84 | Saint Joseph's (210) | Final | W | 35 |
| 2 | 2021-11-12 | Saint Joseph's (92) | 55 | 63 | Drexel (168) | Final | L | -8 |
| 3 | 2021-11-17 | Saint Joseph's (188) | 45 | 57 | Monmouth (229) | Final | L | -12 |
| 4 | 2021-11-20 | Villanova (248) | 55 | 39 | Saint Joseph's (188) | Final | L | -16 |
| 5 | 2021-11-26 | Saint Joseph's (92) | 50 | 67 | Old Dominion (126) | Final | L | -17 |
| 6 | 2021-11-27 | Stetson (151) | 51 | 48 | Saint Joseph's (261) | Final | L | -3 |
| 7 | 2021-11-28 | Saint Joseph's (261) | 67 | 73 | Ball State (96) | Final | L | -6 |
| 8 | 2021-12-04 | Yale (278) | 49 | 52 | Saint Joseph's (92) | Final | W | 3 |
| 9 | 2021-12-07 | Saint Joseph's (253) | 83 | 70 | Penn (200) | Final | W | 13 |
| 10 | 2021-12-11 | Saint Joseph's (253) | 73 | 63 | Temple (115) | Final | W | 10 |
| 11 | 2021-12-21 | Vanderbilt (101) | 64 | 45 | Saint Joseph's (182) | Final | L | -19 |
| 12 | 2021-12-28 | North Alabama | Saint Joseph's | Cancelled | - | - | ||
| 13 | 2021-12-28 | Harvard (66) | 73 | 70 | Saint Joseph's (92) | Final | L | -3 |
| 14 | 2021-12-29 | Saint Joseph's | Norfolk State | Cancelled | - | - | ||
| 15 | 2022-01-01 | Saint Joseph's (188) | 0 | 0 | St. Bonaventure (178) | Postponed | - | - |
| 16 | 2022-01-05 | Saint Joseph's (92) | 0 | 0 | Davidson (79) | Postponed | - | - |
| 17 | 2022-01-08 | George Mason (57) | 0 | 0 | Saint Joseph's (92) | Postponed | - | - |
| 18 | 2022-01-09 | Saint Joseph's (92) | 64 | 72 | Virginia Commonwealth (235) | Final | L | -8 |
| 19 | 2022-01-12 | Richmond (43) | 54 | 74 | Saint Joseph's (92) | Final | W | 20 |
| 20 | 2022-01-17 | La Salle (140) | 69 | 65 | Saint Joseph's (196) | Final | L | -4 |
| 21 | 2022-01-21 | Saint Joseph's (187) | 77 | 70 | St. Bonaventure (230) | Final | W | 7 |
| 22 | 2022-01-26 | Saint Joseph's (175) | 35 | 55 | Fordham (52) | Final | L | -20 |
| 23 | 2022-01-29 | Massachusetts (46) | 74 | 48 | Saint Joseph's (175) | Final | L | -26 |
| 24 | 2022-02-02 | Saint Joseph's (189) | 58 | 66 | La Salle (153) | Final | L | -8 |
| 25 | 2022-02-04 | Saint Joseph's (189) | 67 | 66 | Davidson (102) | Final | W | 1 |
| 26 | 2022-02-06 | Davidson (102) | 51 | 58 | Saint Joseph's (189) | Final | W | 7 |
| 27 | 2022-02-09 | Rhode Island (41) | 58 | 48 | Saint Joseph's (92) | Final | L | -10 |
| 28 | 2022-02-13 | Saint Joseph's (171) | 50 | 45 | George Mason (224) | Final | W | 5 |
| 29 | 2022-02-16 | Saint Joseph's (92) | 46 | 51 | Saint Louis (206) | Final | L | -5 |
| 30 | 2022-02-20 | George Washington (185) | 34 | 57 | Saint Joseph's (167) | Final | W | 23 |
| 31 | 2022-02-23 | Dayton (35) | 59 | 43 | Saint Joseph's (168) | Final | L | -16 |
| 32 | 2022-02-26 | Saint Joseph's (168) | 73 | 68 | Duquesne (172) | Final | W | 5 |
| 33 | 2022-03-03 | Duquesne (179) | 49 | 65 | Saint Joseph's (165) | Final | W | 16 |
| 34 | 2022-03-04 | Saint Joseph's (165) | 51 | 48 | Rhode Island (47) | Final | W | 3 |
| 35 | 2022-03-05 | Saint Joseph's (165) | 58 | 76 | Massachusetts (49) | Final | L | -18 |