NCAA Women's Basketball Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | UMass-Lowell (177) | 47 | 76 | Boston University (88) | Final | L | -29 |
| 2 | 2021-11-13 | Bryant (290) | 54 | 68 | UMass-Lowell (177) | Final | W | 14 |
| 3 | 2021-11-16 | UMass-Lowell (220) | 54 | 73 | Michigan (35) | Final | L | -19 |
| 4 | 2021-11-20 | UMass-Lowell (220) | 47 | 61 | Northeastern (152) | Final | L | -14 |
| 5 | 2021-11-24 | Central Connecticut State (304) | 63 | 70 | UMass-Lowell (283) | Final | W | 7 |
| 6 | 2021-12-01 | UMass-Lowell (251) | 53 | 44 | Cornell (224) | Final | W | 9 |
| 7 | 2021-12-05 | UMass-Lowell (251) | 53 | 58 | Massachusetts (31) | Final | L | -5 |
| 8 | 2021-12-08 | Towson (53) | 70 | 56 | UMass-Lowell (225) | Final | L | -14 |
| 9 | 2021-12-11 | UMass-Lowell (225) | 0 | 0 | Yale (158) | Postponed | - | - |
| 10 | 2021-12-20 | Ohio (128) | 74 | 60 | UMass-Lowell (230) | Final | L | -14 |
| 11 | 2021-12-21 | UMass-Lowell (241) | 0 | 0 | Florida International (200) | Cancelled | - | - |
| 12 | 2021-12-30 | UMass-Lowell (241) | 0 | 0 | New Hampshire (323) | Postponed | - | - |
| 13 | 2022-01-02 | Binghamton (165) | 0 | 0 | UMass-Lowell (330) | Postponed | - | - |
| 14 | 2022-01-05 | UMass-Lowell (330) | 0 | 0 | NJIT (179) | Postponed | - | - |
| 15 | 2022-01-08 | UMBC (182) | 0 | 0 | UMass-Lowell (330) | Postponed | - | - |
| 16 | 2022-01-12 | Albany (207) | 58 | 52 | UMass-Lowell (330) | Final | L | -6 |
| 17 | 2022-01-15 | UMass-Lowell (232) | 0 | 0 | Hartford (354) | Postponed | - | - |
| 18 | 2022-01-17 | UMBC (342) | 72 | 76 | UMass-Lowell (232) | Final | W | 4 |
| 19 | 2022-01-19 | UMass-Lowell (330) | 60 | 55 | Maine (145) | Final | W | 5 |
| 20 | 2022-01-22 | New Hampshire (333) | 54 | 57 | UMass-Lowell (257) | Final | W | 3 |
| 21 | 2022-01-26 | UMass-Lowell (235) | 44 | 56 | Albany (205) | Final | L | -12 |
| 22 | 2022-01-29 | Hartford (351) | 0 | 0 | UMass-Lowell (235) | Postponed | - | - |
| 23 | 2022-01-31 | UMass-Lowell (330) | 0 | 0 | New Hampshire (283) | Postponed | - | - |
| 24 | 2022-02-02 | Maine (214) | 58 | 36 | UMass-Lowell (242) | Final | L | -22 |
| 25 | 2022-02-05 | UMass-Lowell (330) | 55 | 56 | Vermont (85) | Final | L | -1 |
| 26 | 2022-02-07 | UMass-Lowell (330) | 64 | 57 | Hartford (344) | Final | W | 7 |
| 27 | 2022-02-09 | Stony Brook (225) | 69 | 65 | UMass-Lowell (330) | Final | L | -4 |
| 28 | 2022-02-12 | UMass-Lowell (261) | 70 | 68 | UMBC (342) | Final | W | 2 |
| 29 | 2022-02-14 | Binghamton (317) | 53 | 62 | UMass-Lowell (261) | Final | W | 9 |
| 30 | 2022-02-16 | NJIT (179) | 60 | 50 | UMass-Lowell (330) | Final | L | -10 |
| 31 | 2022-02-19 | UMass-Lowell (252) | 54 | 71 | Binghamton (327) | Final | L | -17 |
| 32 | 2022-02-21 | UMass-Lowell (252) | 51 | 58 | NJIT (249) | Final | L | -7 |
| 33 | 2022-02-23 | UMass-Lowell (280) | 70 | 68 | Stony Brook (73) | Final | W | 2 |
| 34 | 2022-02-26 | Vermont (192) | 64 | 44 | UMass-Lowell (280) | Final | L | -20 |
| 35 | 2022-02-28 | Hartford (350) | 46 | 56 | UMass-Lowell (280) | Final | W | 10 |
| 36 | 2022-03-05 | UMass-Lowell (268) | 33 | 47 | NJIT (264) | Final | L | -14 |