NCAA Women's Basketball Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | South Carolina (3) | 66 | 57 | North Carolina State (7) | Final | W | 9 |
| 2 | 2021-11-12 | South Carolina (3) | 72 | 41 | South Dakota (112) | Final | W | 31 |
| 3 | 2021-11-17 | Clemson (144) | 45 | 76 | South Carolina (9) | Final | W | 31 |
| 4 | 2021-11-20 | Buffalo (69) | 60 | 88 | South Carolina (9) | Final | W | 28 |
| 5 | 2021-11-21 | South Carolina (9) | 80 | 63 | Oregon (18) | Final | W | 17 |
| 6 | 2021-11-22 | South Carolina (9) | 73 | 57 | Connecticut (50) | Final | W | 16 |
| 7 | 2021-11-26 | Elon (233) | 38 | 79 | South Carolina (3) | Final | W | 41 |
| 8 | 2021-11-29 | North Carolina A&T (325) | 42 | 79 | South Carolina (1) | Final | W | 37 |
| 9 | 2021-12-03 | Kansas State (17) | 44 | 65 | South Carolina (1) | Final | W | 21 |
| 10 | 2021-12-12 | Maryland (23) | 59 | 66 | South Carolina (1) | Final | W | 7 |
| 11 | 2021-12-15 | South Carolina (1) | 55 | 46 | Duke (15) | Final | W | 9 |
| 12 | 2021-12-21 | Stanford (9) | 61 | 65 | South Carolina (1) | Final | W | 4 |
| 13 | 2021-12-30 | South Carolina (1) | 69 | 70 | Missouri (41) | Final/OT | L | -1 |
| 14 | 2022-01-02 | Mississippi State (51) | 68 | 80 | South Carolina (3) | Final | W | 12 |
| 15 | 2022-01-02 | Ole Miss | South Carolina | Postponed | - | - | ||
| 16 | 2022-01-06 | South Carolina (1) | 66 | 60 | LSU (8) | Final | W | 6 |
| 17 | 2022-01-09 | Kentucky (16) | 54 | 74 | South Carolina (3) | Final | W | 20 |
| 18 | 2022-01-13 | Texas A&M (54) | 45 | 65 | South Carolina (3) | Final | W | 20 |
| 19 | 2022-01-16 | South Carolina (3) | 61 | 52 | Arkansas (114) | Final | W | 9 |
| 20 | 2022-01-24 | Vanderbilt (85) | 30 | 85 | South Carolina (1) | Final | W | 55 |
| 21 | 2022-01-27 | Ole Miss (22) | 40 | 69 | South Carolina (3) | Final | W | 29 |
| 22 | 2022-01-30 | South Carolina (1) | 62 | 50 | Florida (40) | Final | W | 12 |
| 23 | 2022-02-03 | Alabama (76) | 51 | 83 | South Carolina (1) | Final | W | 32 |
| 24 | 2022-02-10 | South Carolina (3) | 59 | 50 | Kentucky (16) | Final | W | 9 |
| 25 | 2022-02-13 | South Carolina (1) | 72 | 54 | Georgia (17) | Final | W | 18 |
| 26 | 2022-02-17 | Auburn (114) | 38 | 75 | South Carolina (1) | Final | W | 37 |
| 27 | 2022-02-20 | Tennessee (6) | 53 | 67 | South Carolina (1) | Final | W | 14 |
| 28 | 2022-02-24 | South Carolina (1) | 89 | 48 | Texas A&M (51) | Final | W | 41 |
| 29 | 2022-02-27 | South Carolina (1) | 71 | 57 | Ole Miss (23) | Final | W | 14 |
| 30 | 2022-03-04 | Arkansas (37) | 54 | 76 | South Carolina (1) | Final | W | 22 |
| 31 | 2022-03-05 | Ole Miss (21) | 51 | 61 | South Carolina (1) | Final | W | 10 |
| 32 | 2022-03-06 | Kentucky (42) | 64 | 62 | South Carolina (1) | Final | L | -2 |
| 33 | 2022-03-18 | Howard (202) | 21 | 79 | South Carolina (1) | Final | W | 58 |
| 34 | 2022-03-20 | Miami (42) | 33 | 49 | South Carolina (1) | Final | W | 16 |
| 35 | 2022-03-25 | North Carolina (11) | 61 | 69 | South Carolina (1) | Final | W | 8 |
| 36 | 2022-03-27 | Creighton (43) | 50 | 80 | South Carolina (1) | Final | W | 30 |
| 37 | 2022-04-01 | Louisville (5) | 59 | 72 | South Carolina (1) | Final | W | 13 |
| 38 | 2022-04-03 | Connecticut (7) | 49 | 64 | South Carolina (1) | Final | W | 15 |