NCAA Women's Basketball Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Charleston Southern (324) | 32 | 109 | Alabama (30) | Final | L | -77 |
| 2 | 2021-11-16 | George Mason (115) | 64 | 55 | Charleston Southern (341) | Final | L | -9 |
| 3 | 2021-11-20 | Charleston Southern (341) | 48 | 74 | Western Carolina (276) | Final | L | -26 |
| 4 | 2021-11-26 | Charleston Southern (317) | 42 | 91 | Auburn (81) | Final | L | -49 |
| 5 | 2021-11-29 | Belmont Abbey | 56 | 48 | Charleston Southern (351) | Final | L | -8 |
| 6 | 2021-12-02 | Charleston (186) | 96 | 60 | Charleston Southern (355) | Final | L | -36 |
| 7 | 2021-12-05 | Charleston Southern (355) | 32 | 83 | Florida State (68) | Final | L | -51 |
| 8 | 2021-12-16 | Furman (221) | 86 | 68 | Charleston Southern (356) | Final | L | -18 |
| 9 | 2021-12-18 | South Alabama (194) | 52 | 51 | Charleston Southern (317) | Final | L | -1 |
| 10 | 2021-12-19 | Charleston Southern (317) | 50 | 55 | Georgia State (250) | Final | L | -5 |
| 11 | 2021-12-21 | Duke (15) | 78 | 35 | Charleston Southern (356) | Final | L | -43 |
| 12 | 2021-12-29 | Charleston Southern (356) | 67 | 54 | Winthrop (355) | Final | W | 13 |
| 13 | 2022-01-01 | High Point (254) | 0 | 0 | Charleston Southern (356) | Postponed | - | - |
| 14 | 2022-01-05 | Charleston Southern (317) | 62 | 99 | Gardner-Webb (303) | Final | L | -37 |
| 15 | 2022-01-08 | Campbell (181) | 61 | 40 | Charleston Southern (317) | Final | L | -21 |
| 16 | 2022-01-12 | Charleston Southern (317) | 58 | 68 | Presbyterian (357) | Final | L | -10 |
| 17 | 2022-01-16 | UNC-Asheville (308) | 59 | 47 | Charleston Southern (317) | Final | L | -12 |
| 18 | 2022-01-19 | Charleston Southern (317) | 50 | 88 | North Carolina A&T (264) | Final | L | -38 |
| 19 | 2022-01-22 | South Carolina Upstate (181) | 53 | 55 | Charleston Southern (355) | Final | W | 2 |
| 20 | 2022-01-25 | Radford (312) | 56 | 52 | Charleston Southern (352) | Final | L | -4 |
| 21 | 2022-01-29 | Charleston Southern (352) | 0 | 0 | Hampton (254) | Suspended | - | - |
| 22 | 2022-02-02 | Charleston Southern (352) | 59 | 91 | Longwood (206) | Final | L | -32 |
| 23 | 2022-02-05 | Presbyterian (357) | 60 | 49 | Charleston Southern (317) | Final | L | -11 |
| 24 | 2022-02-09 | Gardner-Webb (303) | 90 | 51 | Charleston Southern (317) | Final | L | -39 |
| 25 | 2022-02-12 | Charleston Southern (353) | 52 | 63 | Campbell (175) | Final | L | -11 |
| 26 | 2022-02-15 | Winthrop (352) | 56 | 43 | Charleston Southern (355) | Final | L | -13 |
| 27 | 2022-02-17 | High Point (209) | 69 | 60 | Charleston Southern (355) | Final | L | -9 |
| 28 | 2022-02-19 | Charleston Southern (355) | 50 | 71 | High Point (209) | Final | L | -21 |
| 29 | 2022-02-23 | North Carolina A&T (232) | 76 | 42 | Charleston Southern (355) | Final | L | -34 |
| 30 | 2022-02-26 | Charleston Southern (355) | 43 | 63 | UNC-Asheville (335) | Final | L | -20 |
| 31 | 2022-03-01 | Charleston Southern (355) | 34 | 54 | High Point (221) | Final | L | -20 |