NCAA Women's Basketball Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Nicholls State (278) | 40 | 82 | LSU (55) | Final | L | -42 |
| 2 | 2021-11-11 | Tougaloo | 44 | 63 | Nicholls State (273) | Final | W | 19 |
| 3 | 2021-11-16 | Nicholls State (295) | 59 | 75 | Jackson State (216) | Final | L | -16 |
| 4 | 2021-11-19 | Spring Hill | 53 | 73 | Nicholls State (295) | Final | W | 20 |
| 5 | 2021-11-22 | Nicholls State (295) | 48 | 77 | Louisiana Tech (145) | Final | L | -29 |
| 6 | 2021-11-26 | Nicholls State (273) | 55 | 103 | Grand Canyon (176) | Final | L | -48 |
| 7 | 2021-11-27 | Montana (139) | 80 | 45 | Nicholls State (331) | Final | L | -35 |
| 8 | 2021-12-04 | Abilene Christian (137) | 97 | 71 | Nicholls State (273) | Final | L | -26 |
| 9 | 2021-12-11 | South Alabama (324) | 73 | 63 | Nicholls State (334) | Final | L | -10 |
| 10 | 2021-12-14 | Nicholls State (340) | 72 | 100 | DePaul (33) | Final | L | -28 |
| 11 | 2021-12-20 | Nicholls State (340) | 54 | 71 | Memphis (100) | Final | L | -17 |
| 12 | 2021-12-29 | Alabama A&M (296) | 0 | 0 | Nicholls State (340) | Cancelled | - | - |
| 13 | 2022-01-03 | Nicholls State (340) | 0 | 0 | Incarnate Word (275) | Canceled | - | - |
| 14 | 2022-01-15 | Nicholls State (337) | 69 | 68 | New Orleans (344) | Final | W | 1 |
| 15 | 2022-01-20 | Northwestern State (287) | 68 | 64 | Nicholls State (334) | Final | L | -4 |
| 16 | 2022-01-22 | Southeastern Louisiana (237) | 76 | 58 | Nicholls State (334) | Final | L | -18 |
| 17 | 2022-01-27 | Nicholls State (273) | 65 | 73 | McNeese (80) | Final | L | -8 |
| 18 | 2022-01-29 | Nicholls State (335) | 58 | 67 | Houston Baptist (298) | Final | L | -9 |
| 19 | 2022-02-03 | Nicholls State (340) | 47 | 43 | Incarnate Word (314) | Final | W | 4 |
| 20 | 2022-02-10 | Incarnate Word (290) | 78 | 76 | Nicholls State (273) | Final/OT | L | -2 |
| 21 | 2022-02-12 | Texas A&M-Corpus Christi (220) | 64 | 60 | Nicholls State (335) | Final | L | -4 |
| 22 | 2022-02-17 | McNeese State (300) | 63 | 53 | Nicholls State (338) | Final | L | -10 |
| 23 | 2022-02-19 | Houston Baptist (270) | 61 | 51 | Nicholls State (338) | Final | L | -10 |
| 24 | 2022-02-24 | Nicholls State (338) | 60 | 73 | Northwestern State (318) | Final | L | -13 |
| 25 | 2022-02-26 | Nicholls State (338) | 45 | 71 | Southeastern Louisiana (229) | Final | L | -26 |
| 26 | 2022-03-02 | Nicholls State (340) | 53 | 68 | Texas A&M-Corpus Christi (227) | Final | L | -15 |
| 27 | 2022-03-05 | New Orleans (344) | 72 | 67 | Nicholls State (340) | Final | L | -5 |
| 28 | 2022-03-10 | Nicholls State (345) | 73 | 74 | Incarnate Word (319) | Final | L | -1 |