NCAA Women's Basketball Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-10 | Princeton | 59 | 42 | Villanova (53) | Final | L | -17 |
| 2 | 2021-11-12 | Villanova (35) | 67 | 88 | Maryland (18) | Final | L | -21 |
| 3 | 2021-11-20 | Villanova (248) | 55 | 39 | Saint Joseph's (188) | Final | W | 16 |
| 4 | 2021-11-22 | Villanova (248) | 66 | 63 | Penn (76) | Final | W | 3 |
| 5 | 2021-11-27 | Temple (138) | 68 | 62 | Villanova (118) | Final | L | -6 |
| 6 | 2021-12-01 | Lehigh (130) | 60 | 65 | Villanova (166) | Final | W | 5 |
| 7 | 2021-12-03 | Villanova (166) | 47 | 66 | Providence (170) | Final | L | -19 |
| 8 | 2021-12-05 | Villanova (166) | 58 | 72 | Creighton (80) | Final | L | -14 |
| 9 | 2021-12-09 | Villanova (178) | 76 | 67 | James Madison (179) | Final | W | 9 |
| 10 | 2021-12-12 | Oregon State (78) | 52 | 56 | Villanova (178) | Final | W | 4 |
| 11 | 2021-12-21 | Villanova (132) | 66 | 56 | La Salle (158) | Final | W | 10 |
| 12 | 2021-12-31 | Seton Hall (70) | 73 | 76 | Villanova (35) | Final | W | 3 |
| 13 | 2022-01-02 | St. John's (87) | 68 | 70 | Villanova (35) | Final | W | 2 |
| 14 | 2022-01-07 | Connecticut (18) | 0 | 0 | Villanova (107) | Postponed | - | - |
| 15 | 2022-01-09 | Villanova (35) | 0 | 0 | Georgetown (119) | Postponed | - | - |
| 16 | 2022-01-14 | Villanova (102) | 63 | 75 | DePaul (34) | Final | L | -12 |
| 17 | 2022-01-16 | Villanova (35) | 58 | 55 | Marquette (83) | Final | W | 3 |
| 18 | 2022-01-21 | Providence (137) | 56 | 71 | Villanova (89) | Final | W | 15 |
| 19 | 2022-01-23 | Creighton (98) | 64 | 74 | Villanova (35) | Final | W | 10 |
| 20 | 2022-01-28 | Butler (330) | 44 | 59 | Villanova (73) | Final | W | 15 |
| 21 | 2022-01-30 | Xavier (227) | 57 | 82 | Villanova (73) | Final | W | 25 |
| 22 | 2022-02-04 | Villanova (70) | 82 | 58 | St. John's (165) | Final | W | 24 |
| 23 | 2022-02-06 | Georgetown (216) | 57 | 76 | Villanova (70) | Final | W | 19 |
| 24 | 2022-02-09 | Villanova (35) | 72 | 69 | Connecticut (2) | Final | W | 3 |
| 25 | 2022-02-11 | Marquette (54) | 63 | 74 | Villanova (64) | Final/OT | W | 11 |
| 26 | 2022-02-13 | Villanova (64) | 60 | 72 | Seton Hall (94) | Final | L | -12 |
| 27 | 2022-02-20 | DePaul (43) | 64 | 73 | Villanova (56) | Final | W | 9 |
| 28 | 2022-02-22 | Villanova (55) | 73 | 61 | Georgetown (245) | Final | W | 12 |
| 29 | 2022-02-25 | Villanova (35) | 72 | 36 | Butler (157) | Final | W | 36 |
| 30 | 2022-02-27 | Villanova (55) | 58 | 49 | Xavier (234) | Final | W | 9 |
| 31 | 2022-03-05 | St. John's (152) | 52 | 76 | Villanova (57) | Final | W | 24 |
| 32 | 2022-03-06 | Seton Hall (79) | 55 | 64 | Villanova (57) | Final | W | 9 |
| 33 | 2022-03-07 | Villanova (57) | 40 | 70 | Connecticut (8) | Final | L | -30 |
| 34 | 2022-03-19 | Villanova (48) | 61 | 57 | BYU (13) | Final | W | 4 |
| 35 | 2022-03-21 | Villanova (48) | 49 | 64 | Michigan (17) | Final | L | -15 |