NCAA Women's Basketball Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Texas Southern (288) | 71 | 114 | DePaul (52) | Final | L | -43 |
| 2 | 2021-11-15 | Texas Southern (288) | 38 | 93 | Arizona (19) | Final | L | -55 |
| 3 | 2021-11-17 | Texas Southern (318) | 47 | 59 | Rice (236) | Final | L | -12 |
| 4 | 2021-11-23 | Texas Southern (337) | 47 | 79 | Colorado (40) | Final | L | -32 |
| 5 | 2021-12-09 | Texas Southern (311) | 43 | 88 | Texas A&M (9) | Final | L | -45 |
| 6 | 2021-12-12 | Texas Southern (311) | 55 | 96 | LSU (18) | Final | L | -41 |
| 7 | 2021-12-16 | Texas Southern (313) | 0 | 0 | UCLA (91) | Cancelled | - | - |
| 8 | 2021-12-18 | Texas Southern (337) | 45 | 77 | USC (25) | Final | L | -32 |
| 9 | 2021-12-20 | Texas Southern (313) | 0 | 0 | Tulane (92) | Cancelled | - | - |
| 10 | 2021-12-22 | Virginia (194) | 0 | 0 | Texas Southern (311) | Cancelled | - | - |
| 11 | 2022-01-03 | Texas Southern (310) | 60 | 70 | Southern (299) | Final | L | -10 |
| 12 | 2022-01-05 | Texas Southern (337) | 73 | 66 | Grambling (304) | Final | W | 7 |
| 13 | 2022-01-08 | Arkansas-Pine Bluff (306) | 86 | 82 | Texas Southern (337) | Final | L | -4 |
| 14 | 2022-01-10 | Mississippi Valley State (342) | 66 | 100 | Texas Southern (337) | Final | W | 34 |
| 15 | 2022-01-15 | Texas Southern (307) | 63 | 60 | Alcorn State (343) | Final | W | 3 |
| 16 | 2022-01-17 | Texas Southern (307) | 68 | 92 | Jackson State (155) | Final | L | -24 |
| 17 | 2022-01-22 | Alabama A&M (299) | 71 | 67 | Texas Southern (310) | Final | L | -4 |
| 18 | 2022-01-24 | Alabama State (256) | 64 | 67 | Texas Southern (310) | Final | W | 3 |
| 19 | 2022-01-29 | Texas Southern (306) | 91 | 77 | Prairie View A&M (322) | Final | W | 14 |
| 20 | 2022-02-05 | Texas Southern (337) | 74 | 57 | Florida A&M (338) | Final | W | 17 |
| 21 | 2022-02-07 | Texas Southern (337) | 67 | 71 | Bethune-Cookman (352) | Final | L | -4 |
| 22 | 2022-02-12 | Grambling (291) | 86 | 96 | Texas Southern (294) | Final | W | 10 |
| 23 | 2022-02-14 | Southern (251) | 77 | 87 | Texas Southern (294) | Final | W | 10 |
| 24 | 2022-02-19 | Texas Southern (290) | 82 | 77 | Mississippi Valley State (348) | Final | W | 5 |
| 25 | 2022-02-21 | Texas Southern (290) | 84 | 67 | Arkansas-Pine Bluff (281) | Final | W | 17 |
| 26 | 2022-02-26 | Jackson State (111) | 87 | 86 | Texas Southern (282) | Final | L | -1 |
| 27 | 2022-02-28 | Alcorn State (353) | 55 | 62 | Texas Southern (282) | Final | W | 7 |
| 28 | 2022-03-05 | Prairie View A&M (317) | 61 | 56 | Texas Southern (279) | Final | L | -5 |
| 29 | 2022-03-10 | Texas Southern (286) | 67 | 68 | Southern (284) | Final/OT | L | -1 |