NCAA Women's Basketball Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-10 | South Carolina Upstate (309) | 47 | 64 | Clemson (76) | Final | L | -17 |
| 2 | 2021-11-16 | South Carolina Upstate (274) | 70 | 51 | South Carolina State (294) | Final | W | 19 |
| 3 | 2021-11-19 | Columbia International | 40 | 81 | South Carolina Upstate (274) | Final | W | 41 |
| 4 | 2021-11-22 | South Carolina Upstate (274) | 54 | 76 | Florida (218) | Final | L | -22 |
| 5 | 2021-11-28 | Mars Hill | 40 | 102 | South Carolina Upstate (248) | Final | W | 62 |
| 6 | 2021-12-01 | South Carolina Upstate (207) | 58 | 51 | Western Carolina (277) | Final/OT | W | 7 |
| 7 | 2021-12-04 | UNC-Greensboro (254) | 46 | 57 | South Carolina Upstate (315) | Final | W | 11 |
| 8 | 2021-12-13 | Jacksonville (173) | 53 | 70 | South Carolina Upstate (175) | Final | W | 17 |
| 9 | 2021-12-16 | Bob Jones | 36 | 86 | South Carolina Upstate (150) | Final | W | 50 |
| 10 | 2021-12-18 | South Carolina Upstate (315) | 66 | 52 | Morehead State (183) | Final | W | 14 |
| 11 | 2021-12-19 | South Carolina Upstate (315) | 44 | 67 | Kentucky (16) | Final | L | -23 |
| 12 | 2022-01-01 | UNC-Asheville (306) | 53 | 66 | South Carolina Upstate (171) | Final | W | 13 |
| 13 | 2022-01-05 | South Carolina Upstate (315) | 0 | 0 | Winthrop (276) | Postponed | - | - |
| 14 | 2022-01-08 | High Point (103) | 0 | 0 | South Carolina Upstate (315) | Postponed | - | - |
| 15 | 2022-01-11 | Hampton (224) | 0 | 0 | South Carolina Upstate (170) | Postponed | - | - |
| 16 | 2022-01-12 | High Point (103) | 83 | 73 | South Carolina Upstate (315) | Final | L | -10 |
| 17 | 2022-01-15 | North Carolina A&T (280) | 64 | 67 | South Carolina Upstate (170) | Final | W | 3 |
| 18 | 2022-01-19 | South Carolina Upstate (315) | 76 | 69 | Longwood (171) | Final | W | 7 |
| 19 | 2022-01-22 | South Carolina Upstate (181) | 53 | 55 | Charleston Southern (355) | Final | L | -2 |
| 20 | 2022-01-25 | Gardner-Webb (276) | 68 | 71 | South Carolina Upstate (202) | Final | W | 3 |
| 21 | 2022-01-29 | Campbell (150) | 62 | 81 | South Carolina Upstate (202) | Final | W | 19 |
| 22 | 2022-02-01 | South Carolina Upstate (176) | 66 | 55 | Radford (325) | Final | W | 11 |
| 23 | 2022-02-03 | Hampton (259) | 59 | 65 | South Carolina Upstate (176) | Final | W | 6 |
| 24 | 2022-02-05 | South Carolina Upstate (315) | 60 | 58 | Hampton (305) | Final | W | 2 |
| 25 | 2022-02-08 | South Carolina Upstate (315) | 73 | 43 | Winthrop (276) | Final | W | 30 |
| 26 | 2022-02-09 | Winthrop (276) | 47 | 59 | South Carolina Upstate (315) | Final | W | 12 |
| 27 | 2022-02-12 | South Carolina Upstate (169) | 59 | 75 | High Point (229) | Final | L | -16 |
| 28 | 2022-02-15 | Presbyterian (314) | 66 | 68 | South Carolina Upstate (182) | Final | W | 2 |
| 29 | 2022-02-16 | South Carolina Upstate (315) | 80 | 67 | Presbyterian (357) | Final | W | 13 |
| 30 | 2022-02-19 | South Carolina Upstate (182) | 68 | 57 | UNC-Asheville (330) | Final | W | 11 |
| 31 | 2022-02-23 | Longwood (194) | 71 | 66 | South Carolina Upstate (182) | Final | L | -5 |
| 32 | 2022-02-26 | South Carolina Upstate (182) | 74 | 63 | North Carolina A&T (232) | Final | W | 11 |
| 33 | 2022-03-03 | UNC-Asheville (332) | 62 | 57 | South Carolina Upstate (180) | Final | L | -5 |