Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2016-09-03 | Southern Illinois | 30 | Florida Atlantic | 38 | Final | L | -8 |
| 2 | 2016-09-10 | Southeast Missouri State | 22 | Southern Illinois | 30 | Final | W | 8 |
| 3 | 2016-09-17 | Murray State | 17 | Southern Illinois | 50 | Final | W | 33 |
| 4 | 2016-10-01 | Southern Illinois | 21 | Northern Iowa | 42 | Final | L | -21 |
| 5 | 2016-10-08 | South Dakota State | 45 | Southern Illinois | 39 | Final | L | -6 |
| 6 | 2016-10-15 | Southern Illinois | 28 | Illinois State | 31 | Final | L | -3 |
| 7 | 2016-10-22 | Indiana State | 22 | Southern Illinois | 14 | Final | L | -8 |
| 8 | 2016-10-29 | Southern Illinois | 35 | Missouri State | 38 | Final | L | -3 |
| 9 | 2016-11-05 | South Dakota | 28 | Southern Illinois | 35 | Final | W | 7 |
| 10 | 2016-11-12 | Southern Illinois | 14 | Youngstown State | 21 | Final | L | -7 |
| 11 | 2016-11-19 | Western Illinois | 34 | Southern Illinois | 44 | Final | W | 10 |