Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2016-09-03 | Valparaiso | 13 | Illinois State | 50 | Final | W | 37 |
| 2 | 2016-09-10 | Illinois State | 9 | Northwestern | 7 | Final | W | 2 |
| 3 | 2016-09-17 | Eastern Illinois | 24 | Illinois State | 21 | Final | L | -3 |
| 4 | 2016-09-24 | Illinois State | 31 | Indiana State | 34 | Final | L | -3 |
| 5 | 2016-10-01 | Illinois State | 10 | North Dakota State | 31 | Final | L | -21 |
| 6 | 2016-10-08 | Youngstown State | 20 | Illinois State | 6 | Final | L | -14 |
| 7 | 2016-10-15 | Southern Illinois | 28 | Illinois State | 31 | Final | W | 3 |
| 8 | 2016-10-22 | Illinois State | 24 | South Dakota | 27 | Final | L | -3 |
| 9 | 2016-10-29 | South Dakota State | 21 | Illinois State | 38 | Final | W | 17 |
| 10 | 2016-11-05 | Illinois State | 31 | Western Illinois | 26 | Final | W | 5 |
| 11 | 2016-11-12 | Missouri State (178) | 0 | Illinois State (159) | 37 | Final | W | 37 |
| 12 | 2016-11-26 | Illinois State | 24 | Central Arkansas | 31 | Final | L | -7 |