Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2016-09-03 | Butler | 25 | Indiana State | 41 | Final | W | 16 |
| 2 | 2016-09-10 | Indiana State | 28 | Minnesota | 58 | Final | L | -30 |
| 3 | 2016-09-17 | Indiana State | 27 | Southeast Missouri State | 24 | Final | W | 3 |
| 4 | 2016-09-24 | Illinois State | 31 | Indiana State | 34 | Final | W | 3 |
| 5 | 2016-10-01 | Missouri State | 45 | Indiana State | 24 | Final | L | -21 |
| 6 | 2016-10-08 | Indiana State | 35 | Western Illinois | 36 | Final | L | -1 |
| 7 | 2016-10-15 | South Dakota | 33 | Indiana State | 30 | Final/2OT | L | -3 |
| 8 | 2016-10-22 | Indiana State | 22 | Southern Illinois | 14 | Final | W | 8 |
| 9 | 2016-10-29 | Indiana State | 10 | Youngstown State | 13 | Final | L | -3 |
| 10 | 2016-11-05 | Northern Iowa (153) | 39 | Indiana State (181) | 6 | Final | L | -33 |
| 11 | 2016-11-12 | Indiana State | 17 | North Dakota State | 41 | Final | L | -24 |