Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2016-09-03 | Southeast Missouri State | 17 | Memphis | 35 | Final | L | -18 |
| 2 | 2016-09-10 | Southeast Missouri State | 22 | Southern Illinois | 30 | Final | L | -8 |
| 3 | 2016-09-17 | Indiana State | 27 | Southeast Missouri State | 24 | Final | L | -3 |
| 4 | 2016-09-24 | Southeast Missouri State | 17 | Murray State | 16 | Final | W | 1 |
| 5 | 2016-10-01 | Eastern Illinois | 14 | Southeast Missouri State | 21 | Final | W | 7 |
| 6 | 2016-10-08 | Southeast Missouri State | 16 | Eastern Kentucky | 31 | Final | L | -15 |
| 7 | 2016-10-22 | Southeast Missouri State | 20 | Tennessee Tech | 21 | Final | L | -1 |
| 8 | 2016-10-29 | Austin Peay | 21 | Southeast Missouri State | 41 | Final | W | 20 |
| 9 | 2016-11-05 | Jacksonville State | 17 | Southeast Missouri State | 10 | Final | L | -7 |
| 10 | 2016-11-12 | Southeast Missouri State | 10 | Tennessee-Martin | 24 | Final | L | -14 |
| 11 | 2016-11-19 | Tennessee State | 32 | Southeast Missouri State | 31 | Final | L | -1 |