Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2016-09-03 | Murray State | 3 | Illinois | 52 | Final | L | -49 |
| 2 | 2016-09-10 | Missouri State | 28 | Murray State | 22 | Final | L | -6 |
| 3 | 2016-09-17 | Murray State | 17 | Southern Illinois | 50 | Final | L | -33 |
| 4 | 2016-09-24 | Southeast Missouri State | 17 | Murray State | 16 | Final | L | -1 |
| 5 | 2016-10-01 | Murray State | 45 | Austin Peay | 17 | Final | W | 28 |
| 6 | 2016-10-15 | Tennessee-Martin | 38 | Murray State | 31 | Final | L | -7 |
| 7 | 2016-10-22 | Murray State | 40 | Eastern Illinois | 38 | Final | W | 2 |
| 8 | 2016-10-29 | Tennessee State | 31 | Murray State | 38 | Final | W | 7 |
| 9 | 2016-11-05 | Murray State | 41 | Eastern Kentucky | 28 | Final | W | 13 |
| 10 | 2016-11-12 | Jacksonville State | 33 | Murray State | 15 | Final | L | -18 |
| 11 | 2016-11-19 | Murray State | 19 | Tennessee Tech | 55 | Final | L | -36 |