Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2016-09-01 | Southwestern | 0 | Missouri State | 57 | Final | W | 57 |
| 2 | 2016-09-10 | Missouri State | 28 | Murray State | 22 | Final | W | 6 |
| 3 | 2016-09-24 | Missouri State | 0 | Kansas State | 35 | Final | L | -35 |
| 4 | 2016-10-01 | Missouri State | 45 | Indiana State | 24 | Final | W | 21 |
| 5 | 2016-10-08 | North Dakota State | 27 | Missouri State | 3 | Final | L | -24 |
| 6 | 2016-10-15 | Western Illinois | 38 | Missouri State | 35 | Final | L | -3 |
| 7 | 2016-10-22 | Missouri State | 7 | Northern Iowa | 61 | Final | L | -54 |
| 8 | 2016-10-29 | Southern Illinois | 35 | Missouri State | 38 | Final | W | 3 |
| 9 | 2016-11-05 | Missouri State | 24 | South Dakota State | 49 | Final | L | -25 |
| 10 | 2016-11-12 | Missouri State (178) | 0 | Illinois State (159) | 37 | Final | L | -37 |
| 11 | 2016-11-19 | Youngstown State | 65 | Missouri State | 20 | Final | L | -45 |