Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2016-09-01 | Western Illinois | 38 | Eastern Illinois | 21 | Final | W | 17 |
| 2 | 2016-09-10 | Northern Arizona | 20 | Western Illinois | 34 | Final | W | 14 |
| 3 | 2016-09-24 | Western Illinois | 28 | Northern Illinois | 23 | Final | W | 5 |
| 4 | 2016-10-01 | Western Illinois | 14 | South Dakota State | 52 | Final | L | -38 |
| 5 | 2016-10-08 | Indiana State | 35 | Western Illinois | 36 | Final | W | 1 |
| 6 | 2016-10-15 | Western Illinois | 38 | Missouri State | 35 | Final | W | 3 |
| 7 | 2016-10-22 | North Dakota State | 21 | Western Illinois | 13 | Final | L | -8 |
| 8 | 2016-10-29 | Western Illinois | 35 | South Dakota | 34 | Final | W | 1 |
| 9 | 2016-11-05 | Illinois State | 31 | Western Illinois | 26 | Final | L | -5 |
| 10 | 2016-11-12 | Northern Iowa | 30 | Western Illinois | 23 | Final | L | -7 |
| 11 | 2016-11-19 | Western Illinois | 34 | Southern Illinois | 44 | Final | L | -10 |