Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2016-09-03 | South Dakota State | 41 | TCU | 59 | Final | L | -18 |
| 2 | 2016-09-10 | Drake | 28 | South Dakota State | 56 | Final | W | 28 |
| 3 | 2016-09-17 | Cal Poly | 38 | South Dakota State | 31 | Final | L | -7 |
| 4 | 2016-10-01 | Western Illinois | 14 | South Dakota State | 52 | Final | W | 38 |
| 5 | 2016-10-08 | South Dakota State | 45 | Southern Illinois | 39 | Final | W | 6 |
| 6 | 2016-10-15 | South Dakota State | 19 | North Dakota State | 17 | Final | W | 2 |
| 7 | 2016-10-22 | Youngstown State | 10 | South Dakota State | 24 | Final | W | 14 |
| 8 | 2016-10-29 | South Dakota State | 21 | Illinois State | 38 | Final | L | -17 |
| 9 | 2016-11-05 | Missouri State | 24 | South Dakota State | 49 | Final | W | 25 |
| 10 | 2016-11-12 | South Dakota | 21 | South Dakota State | 28 | Final | W | 7 |
| 11 | 2016-11-19 | South Dakota State | 45 | Northern Iowa | 24 | Final | W | 21 |
| 12 | 2016-12-03 | Villanova | 7 | South Dakota State | 10 | Final | W | 3 |
| 13 | 2016-12-10 | South Dakota State | 10 | North Dakota State | 36 | Final | L | -26 |