Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-09-01 | Lamar (249) | 14 | Abilene Christian (205) | 28 | Final | L | -14 |
| 2 | 2022-09-10 | Lamar (249) | 16 | SMU (45) | 45 | Final | L | -29 |
| 3 | 2022-09-17 | Northern Colorado (209) | 21 | Lamar (250) | 14 | Final | L | -7 |
| 4 | 2022-09-24 | Lamar (257) | 27 | Northwestern State (238) | 35 | Final | L | -8 |
| 5 | 2022-10-01 | Houston Christian | 37 | Lamar (259) | 34 | Final | L | -3 |
| 6 | 2022-10-08 | Lamar (259) | 17 | Incarnate Word (124) | 56 | Final | L | -39 |
| 7 | 2022-10-22 | Prairie View A&M (176) | 54 | Lamar (258) | 21 | Final | L | -33 |
| 8 | 2022-10-29 | Nicholls State (246) | 17 | Lamar (256) | 24 | Final | W | 7 |
| 9 | 2022-11-05 | Southeastern Louisiana (155) | 47 | Lamar (254) | 31 | Final | L | -16 |
| 10 | 2022-11-12 | Lamar (251) | 14 | New Mexico State (135) | 51 | Final | L | -37 |
| 11 | 2022-11-19 | Lamar (256) | 20 | McNeese State (236) | 24 | Final | L | -4 |