Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-08-27 | Howard (243) | 13 | Alabama State (224) | 23 | Final | W | 10 |
| 2 | 2022-09-01 | Miles | 13 | Alabama State (224) | 21 | Final | W | 8 |
| 3 | 2022-09-03 | Miles | 13 | Alabama State (224) | 21 | Final | W | 8 |
| 4 | 2022-09-10 | Alabama State (224) | 7 | UCLA (44) | 45 | Final | L | -38 |
| 5 | 2022-09-24 | Prairie View A&M (181) | 25 | Alabama State (186) | 15 | Final | L | -10 |
| 6 | 2022-09-24 | Prairie View A&M (170) | 24 | Alabama State (225) | 15 | Final | L | -9 |
| 7 | 2022-10-01 | Alabama State (197) | 16 | Texas Southern (204) | 13 | Final | W | 3 |
| 8 | 2022-10-08 | Jackson State (135) | 26 | Alabama State (211) | 12 | Final | L | -14 |
| 9 | 2022-10-14 | Mississippi Valley State (260) | 9 | Alabama State (211) | 24 | Final | W | 15 |
| 10 | 2022-10-15 | Mississippi Valley State (260) | 9 | Alabama State (207) | 24 | Final | W | 15 |
| 11 | 2022-10-29 | Alabama State (191) | 24 | Alabama A&M (214) | 17 | Final | W | 7 |
| 12 | 2022-11-05 | Alabama State (190) | 37 | Bethune-Cookman (243) | 22 | Final | W | 15 |
| 13 | 2022-11-12 | Florida A&M (168) | 21 | Alabama State (196) | 14 | Final | L | -7 |
| 14 | 2022-11-24 | Arkansas-Pine Bluff (252) | 19 | Alabama State (202) | 14 | Final | L | -5 |