Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-09-01 | Mississippi Valley State (209) | 13 | Tarleton State (213) | 29 | Final | L | -16 |
| 2 | 2022-09-10 | Mississippi Valley State (209) | 0 | Austin Peay (169) | 41 | Final | L | -41 |
| 3 | 2022-09-17 | Delta State | 28 | Mississippi Valley State (260) | 17 | Final | L | -11 |
| 4 | 2022-09-24 | Mississippi Valley State (260) | 7 | Jackson State (136) | 49 | Final | L | -42 |
| 5 | 2022-10-01 | Mississippi Valley State (260) | 7 | Florida A&M (196) | 34 | Final | L | -27 |
| 6 | 2022-10-08 | Alcorn State (194) | 30 | Mississippi Valley State (260) | 7 | Final | L | -23 |
| 7 | 2022-10-14 | Mississippi Valley State (260) | 9 | Alabama State (211) | 24 | Final | L | -15 |
| 8 | 2022-10-15 | Mississippi Valley State (260) | 9 | Alabama State (207) | 24 | Final | L | -15 |
| 9 | 2022-10-22 | Bethune-Cookman (236) | 45 | Mississippi Valley State (260) | 35 | Final | L | -10 |
| 10 | 2022-11-03 | Alabama A&M (229) | 20 | Mississippi Valley State (259) | 30 | Final | W | 10 |
| 11 | 2022-11-12 | Mississippi Valley State (259) | 7 | Southern (176) | 27 | Final | L | -20 |
| 12 | 2022-11-19 | Prairie View A&M (193) | 7 | Mississippi Valley State (254) | 27 | Final | W | 20 |