Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2016-09-03 | Villanova | 7 | Pittsburgh | 28 | Final | W | 21 |
| 2 | 2016-09-10 | Penn State | 39 | Pittsburgh | 42 | Final | W | 3 |
| 3 | 2016-09-17 | Pittsburgh | 38 | Oklahoma State | 45 | Final | L | -7 |
| 4 | 2016-09-24 | Pittsburgh | 36 | North Carolina | 37 | Final | L | -1 |
| 5 | 2016-10-01 | Marshall | 27 | Pittsburgh | 43 | Final | W | 16 |
| 6 | 2016-10-08 | Georgia Tech | 34 | Pittsburgh | 37 | Final | W | 3 |
| 7 | 2016-10-15 | Pittsburgh | 45 | Virginia | 31 | Final | W | 14 |
| 8 | 2016-10-27 | Virginia Tech | 39 | Pittsburgh | 36 | Final | L | -3 |
| 9 | 2016-11-05 | Pittsburgh | 28 | Miami | 51 | Final | L | -23 |
| 10 | 2016-11-12 | Pittsburgh | 43 | Clemson | 42 | Final | W | 1 |
| 11 | 2016-11-19 | Duke | 14 | Pittsburgh | 56 | Final | W | 42 |
| 12 | 2016-11-26 | Syracuse | 61 | Pittsburgh | 76 | Final | W | 15 |
| 13 | 2016-12-28 | Pittsburgh | 24 | Northwestern | 31 | Final | L | -7 |