Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2016-09-03 | North Carolina Central | 6 | Duke | 49 | Final | W | 43 |
| 2 | 2016-09-10 | Wake Forest (90) | 24 | Duke (58) | 14 | Final | L | -10 |
| 3 | 2016-09-17 | Duke (58) | 13 | Northwestern (27) | 24 | Final | L | -11 |
| 4 | 2016-09-24 | Duke (111) | 38 | Notre Dame (77) | 35 | Final | W | 3 |
| 5 | 2016-10-01 | Virginia (119) | 34 | Duke (85) | 20 | Final | L | -14 |
| 6 | 2016-10-08 | Army (53) | 6 | Duke (98) | 13 | Final | W | 7 |
| 7 | 2016-10-14 | Duke (83) | 14 | Louisville (8) | 24 | Final | L | -10 |
| 8 | 2016-10-29 | Duke (85) | 35 | Georgia Tech (52) | 38 | Final | L | -3 |
| 9 | 2016-11-05 | Virginia Tech (20) | 24 | Duke (89) | 21 | Final | L | -3 |
| 10 | 2016-11-10 | North Carolina (28) | 27 | Duke (93) | 28 | Final | W | 1 |
| 11 | 2016-11-19 | Duke | 14 | Pittsburgh | 56 | Final | L | -42 |
| 12 | 2016-11-26 | Duke (82) | 21 | Miami (31) | 40 | Final | L | -19 |