Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2016-09-02 | Colgate | 7 | Syracuse | 33 | Final | W | 26 |
| 2 | 2016-09-09 | Louisville (39) | 62 | Syracuse (69) | 28 | Final | L | -34 |
| 3 | 2016-09-17 | South Florida | 45 | Syracuse | 20 | Final | L | -25 |
| 4 | 2016-09-24 | Syracuse | 31 | Connecticut | 24 | Final | W | 7 |
| 5 | 2016-10-01 | Notre Dame (96) | 50 | Syracuse (76) | 33 | Final | L | -17 |
| 6 | 2016-10-08 | Syracuse (95) | 9 | Wake Forest (28) | 28 | Final | L | -19 |
| 7 | 2016-10-15 | Virginia Tech (17) | 17 | Syracuse (96) | 31 | Final | W | 14 |
| 8 | 2016-10-22 | Syracuse (79) | 28 | Boston College (84) | 20 | Final | W | 8 |
| 9 | 2016-11-05 | Syracuse (72) | 0 | Clemson (3) | 54 | Final | L | -54 |
| 10 | 2016-11-12 | North Carolina State | 35 | Syracuse | 20 | Final | L | -15 |
| 11 | 2016-11-19 | Florida State (21) | 45 | Syracuse (84) | 14 | Final | L | -31 |
| 12 | 2016-11-26 | Syracuse | 61 | Pittsburgh | 76 | Final | L | -15 |