Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2016-09-03 | Kent State (104) | 13 | Penn State (55) | 33 | Final | W | 20 |
| 2 | 2016-09-10 | Penn State | 39 | Pittsburgh | 42 | Final | L | -3 |
| 3 | 2016-09-17 | Temple (30) | 27 | Penn State (55) | 34 | Final | W | 7 |
| 4 | 2016-09-24 | Penn State (56) | 10 | Michigan (4) | 49 | Final | L | -39 |
| 5 | 2016-10-01 | Minnesota (30) | 26 | Penn State (72) | 29 | Final/OT | W | 3 |
| 6 | 2016-10-08 | Maryland (16) | 14 | Penn State (48) | 38 | Final | W | 24 |
| 7 | 2016-10-22 | Ohio State (4) | 21 | Penn State (28) | 24 | Final | W | 3 |
| 8 | 2016-10-29 | Penn State (18) | 62 | Purdue (98) | 24 | Final | W | 38 |
| 9 | 2016-11-05 | Iowa (55) | 14 | Penn State (12) | 41 | Final | W | 27 |
| 10 | 2016-11-12 | Penn State (11) | 45 | Indiana (59) | 31 | Final | W | 14 |
| 11 | 2016-11-19 | Penn State (9) | 39 | Rutgers (120) | 0 | Final | W | 39 |
| 12 | 2016-11-26 | Michigan State (89) | 12 | Penn State (8) | 45 | Final | W | 33 |
| 13 | 2016-12-03 | Wisconsin (7) | 31 | Penn State (8) | 38 | Final | W | 7 |
| 14 | 2017-01-02 | USC (11) | 52 | Penn State (6) | 49 | Final | L | -3 |