Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2016-09-10 | Morgan State | 0 | Marshall | 62 | Final | W | 62 |
| 2 | 2016-09-17 | Akron (77) | 65 | Marshall (67) | 38 | Final | L | -27 |
| 3 | 2016-09-24 | Louisville (2) | 59 | Marshall (86) | 28 | Final | L | -31 |
| 4 | 2016-10-01 | Marshall | 27 | Pittsburgh | 43 | Final | L | -16 |
| 5 | 2016-10-08 | Marshall (99) | 21 | North Texas (107) | 38 | Final | L | -17 |
| 6 | 2016-10-15 | Florida Atlantic | 21 | Marshall | 27 | Final | W | 6 |
| 7 | 2016-10-22 | Charlotte (117) | 27 | Marshall (110) | 24 | Final | L | -3 |
| 8 | 2016-10-29 | Marshall (116) | 14 | Southern Miss (69) | 24 | Final | L | -10 |
| 9 | 2016-11-05 | Marshall (128) | 14 | Old Dominion (74) | 38 | Final | L | -24 |
| 10 | 2016-11-12 | Middle Tennessee | 17 | Marshall | 42 | Final | W | 25 |
| 11 | 2016-11-19 | Marshall | 14 | Florida International | 31 | Final | L | -17 |
| 12 | 2016-11-26 | Western Kentucky | 60 | Marshall | 6 | Final | L | -54 |