Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2016-09-03 | Liberty | 13 | Virginia Tech | 36 | Final | W | 23 |
| 2 | 2016-09-10 | Virginia Tech (54) | 24 | Tennessee (18) | 45 | Final | L | -21 |
| 3 | 2016-09-17 | Boston College (88) | 0 | Virginia Tech (54) | 49 | Final | W | 49 |
| 4 | 2016-09-24 | East Carolina (51) | 17 | Virginia Tech (43) | 54 | Final | W | 37 |
| 5 | 2016-10-08 | Virginia Tech (23) | 34 | North Carolina (26) | 3 | Final | W | 31 |
| 6 | 2016-10-15 | Virginia Tech (17) | 17 | Syracuse (96) | 31 | Final | L | -14 |
| 7 | 2016-10-20 | Miami (26) | 16 | Virginia Tech (37) | 37 | Final | W | 21 |
| 8 | 2016-10-27 | Virginia Tech | 39 | Pittsburgh | 36 | Final | W | 3 |
| 9 | 2016-11-05 | Virginia Tech (20) | 24 | Duke (89) | 21 | Final | W | 3 |
| 10 | 2016-11-12 | Georgia Tech (50) | 30 | Virginia Tech (23) | 20 | Final | L | -10 |
| 11 | 2016-11-19 | Virginia Tech (31) | 34 | Notre Dame (73) | 31 | Final | W | 3 |
| 12 | 2016-11-26 | Virginia (122) | 10 | Virginia Tech (28) | 52 | Final | W | 42 |
| 13 | 2016-12-03 | Clemson (4) | 42 | Virginia Tech (28) | 35 | Final | L | -7 |
| 14 | 2016-12-29 | Arkansas (48) | 24 | Virginia Tech (29) | 35 | Final | W | 11 |