Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2016-09-03 | Southeastern Louisiana | 7 | Oklahoma State | 61 | Final | W | 54 |
| 2 | 2016-09-10 | Central Michigan | 30 | Oklahoma State | 27 | Final | L | -3 |
| 3 | 2016-09-17 | Pittsburgh | 38 | Oklahoma State | 45 | Final | W | 7 |
| 4 | 2016-09-24 | Oklahoma State (38) | 24 | Baylor (17) | 35 | Final | L | -11 |
| 5 | 2016-10-01 | Texas (53) | 31 | Oklahoma State (63) | 49 | Final | W | 18 |
| 6 | 2016-10-08 | Iowa State (123) | 31 | Oklahoma State (45) | 38 | Final | W | 7 |
| 7 | 2016-10-22 | Oklahoma State (43) | 44 | Kansas (116) | 20 | Final | W | 24 |
| 8 | 2016-10-29 | West Virginia (11) | 20 | Oklahoma State (39) | 37 | Final | W | 17 |
| 9 | 2016-11-05 | Oklahoma State (30) | 43 | Kansas State (46) | 37 | Final | W | 6 |
| 10 | 2016-11-12 | Texas Tech (71) | 44 | Oklahoma State (33) | 45 | Final | W | 1 |
| 11 | 2016-11-19 | Oklahoma State (28) | 31 | TCU (56) | 6 | Final | W | 25 |
| 12 | 2016-12-03 | Oklahoma State (24) | 20 | Oklahoma (10) | 38 | Final | L | -18 |
| 13 | 2016-12-29 | Oklahoma State (28) | 38 | Colorado (10) | 8 | Final | W | 30 |