Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2016-09-03 | Clemson (2) | 19 | Auburn (48) | 13 | Final | W | 6 |
| 2 | 2016-09-10 | Troy (96) | 24 | Clemson (2) | 30 | Final | W | 6 |
| 3 | 2016-09-17 | South Carolina State | 0 | Clemson | 59 | Final | W | 59 |
| 4 | 2016-09-22 | Clemson (9) | 26 | Georgia Tech (18) | 7 | Final | W | 19 |
| 5 | 2016-10-01 | Louisville (2) | 36 | Clemson (5) | 42 | Final | W | 6 |
| 6 | 2016-10-07 | Clemson (2) | 56 | Boston College (70) | 10 | Final | W | 46 |
| 7 | 2016-10-15 | North Carolina State | 17 | Clemson | 24 | Final/OT | W | 7 |
| 8 | 2016-10-29 | Clemson (3) | 37 | Florida State (20) | 34 | Final | W | 3 |
| 9 | 2016-11-05 | Syracuse (72) | 0 | Clemson (3) | 54 | Final | W | 54 |
| 10 | 2016-11-12 | Pittsburgh | 43 | Clemson | 42 | Final | L | -1 |
| 11 | 2016-11-19 | Clemson (4) | 35 | Wake Forest (62) | 13 | Final | W | 22 |
| 12 | 2016-11-26 | South Carolina (63) | 7 | Clemson (4) | 56 | Final | W | 49 |
| 13 | 2016-12-03 | Clemson (4) | 42 | Virginia Tech (28) | 35 | Final | W | 7 |
| 14 | 2016-12-31 | Ohio State (2) | 0 | Clemson (5) | 31 | Final | W | 31 |
| 15 | 2017-01-09 | Clemson (5) | 35 | Alabama (1) | 31 | Final | W | 4 |