Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2016-09-03 | Western Michigan | 22 | Northwestern | 21 | Final | L | -1 |
| 2 | 2016-09-10 | Illinois State | 9 | Northwestern | 7 | Final | L | -2 |
| 3 | 2016-09-17 | Duke (58) | 13 | Northwestern (27) | 24 | Final | W | 11 |
| 4 | 2016-09-24 | Nebraska (7) | 24 | Northwestern (112) | 13 | Final | L | -11 |
| 5 | 2016-10-01 | Northwestern (102) | 38 | Iowa (70) | 31 | Final | W | 7 |
| 6 | 2016-10-15 | Northwestern (77) | 54 | Michigan State (89) | 40 | Final | W | 14 |
| 7 | 2016-10-22 | Indiana (51) | 14 | Northwestern (63) | 24 | Final | W | 10 |
| 8 | 2016-10-29 | Northwestern (53) | 20 | Ohio State (8) | 24 | Final | L | -4 |
| 9 | 2016-11-05 | Wisconsin (10) | 21 | Northwestern (50) | 7 | Final | L | -14 |
| 10 | 2016-11-12 | Northwestern (58) | 45 | Purdue (107) | 17 | Final | W | 28 |
| 11 | 2016-11-19 | Northwestern (49) | 12 | Minnesota (43) | 29 | Final | L | -17 |
| 12 | 2016-11-26 | Illinois (97) | 21 | Northwestern (51) | 42 | Final | W | 21 |
| 13 | 2016-12-28 | Pittsburgh | 24 | Northwestern | 31 | Final | W | 7 |