Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2016-09-03 | Florida A&M | 3 | Miami | 70 | Final | W | 67 |
| 2 | 2016-09-10 | Florida Atlantic | 10 | Miami | 38 | Final | W | 28 |
| 3 | 2016-09-17 | Miami | 45 | Appalachian State | 10 | Final | W | 35 |
| 4 | 2016-10-01 | Miami (11) | 35 | Georgia Tech (32) | 21 | Final | W | 14 |
| 5 | 2016-10-08 | Florida State (34) | 20 | Miami (7) | 19 | Final | L | -1 |
| 6 | 2016-10-15 | North Carolina (41) | 20 | Miami (15) | 13 | Final | L | -7 |
| 7 | 2016-10-20 | Miami (26) | 16 | Virginia Tech (37) | 37 | Final | L | -21 |
| 8 | 2016-10-29 | Miami (37) | 27 | Notre Dame (99) | 30 | Final | L | -3 |
| 9 | 2016-11-05 | Pittsburgh | 28 | Miami | 51 | Final | W | 23 |
| 10 | 2016-11-12 | Miami (40) | 34 | Virginia (118) | 14 | Final | W | 20 |
| 11 | 2016-11-19 | Miami | 27 | North Carolina State | 13 | Final | W | 14 |
| 12 | 2016-11-26 | Duke (82) | 21 | Miami (31) | 40 | Final | W | 19 |
| 13 | 2016-12-28 | West Virginia (18) | 14 | Miami (30) | 31 | Final | W | 17 |